Q3U595 · CV039_MOUSE
- ProteinSynaptic plasticity regulator PANTS
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids105 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Negatively regulates long-term potentiation and modulates adult synaptic plasticity (PubMed:35771867).
Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites (PubMed:35771867).
Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses (PubMed:35771867).
Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites (PubMed:35771867).
Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses (PubMed:35771867).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | synapse | |
Cellular Component | synaptic cleft | |
Biological Process | negative regulation of long-term synaptic potentiation | |
Biological Process | regulation of synaptic plasticity |
Names & Taxonomy
Protein names
- Recommended nameSynaptic plasticity regulator PANTS
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3U595
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000326131 | 1-105 | Synaptic plasticity regulator PANTS | |||
Sequence: MAVAGSWQPPRPCEVYRAEWELCRSVGHVLHHYYVHGKRPDCRQWLRDLTNCREWEESRSAEAQRSLCESEQVRVQAAQKHTLVWALRQRPPTDWNLPLPQEKDK |
Post-translational modification
Rapidly degraded by proteolysis following neuronal stimulation, resulting in increased AMPA receptor clustering.
Proteomic databases
PTM databases
Expression
Tissue specificity
In the postnatal brain, expressed diffusely throughout the hippocampus at a low level at 8 weeks (at protein level) (PubMed:29571919).
At 16 weeks, strongly expressed in the stratum lucidum of the hippocampus (at protein level) (PubMed:29571919).
In developing and aging brain, expression is strongest in hippocampus, especially in areas CA3 and CA2, throughout the dorsoventral axis (PubMed:29571919).
At 16 weeks, strongly expressed in the stratum lucidum of the hippocampus (at protein level) (PubMed:29571919).
In developing and aging brain, expression is strongest in hippocampus, especially in areas CA3 and CA2, throughout the dorsoventral axis (PubMed:29571919).
Developmental stage
Expression increases in the hippocampus between 8 and 16 weeks of age (at protein level) (PubMed:35771867).
In brain, expression decreases steadily throughout embryonic development (PubMed:29571919).
In liver, expression decreases between 11.5 dpc and 13.5 dpc and then remains relatively low (PubMed:29571919).
Expression in the heart shows a 50% increase between 11.5 dpc and 13.5 dpc and then decreases (PubMed:29571919).
In the postnatal brain, cerebellum levels decline (PubMed:29571919).
In cortical tissue, expression significantly decreases by ~40% between P0 and 3 weeks and then returns to levels comparable to P0 in adult stages (PubMed:29571919).
In the hippocampus, expression significantly drops by 40% between P0 and 3 weeks with a slight increase observed between 8 and 16 weeks of age (PubMed:29571919).
In brain, expression decreases steadily throughout embryonic development (PubMed:29571919).
In liver, expression decreases between 11.5 dpc and 13.5 dpc and then remains relatively low (PubMed:29571919).
Expression in the heart shows a 50% increase between 11.5 dpc and 13.5 dpc and then decreases (PubMed:29571919).
In the postnatal brain, cerebellum levels decline (PubMed:29571919).
In cortical tissue, expression significantly decreases by ~40% between P0 and 3 weeks and then returns to levels comparable to P0 in adult stages (PubMed:29571919).
In the hippocampus, expression significantly drops by 40% between P0 and 3 weeks with a slight increase observed between 8 and 16 weeks of age (PubMed:29571919).
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length105
- Mass (Da)12,503
- Last updated2005-10-11 v1
- ChecksumC312496CC7F3E53E
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087WS89 | A0A087WS89_MOUSE | 2510002D24Rik | 71 | ||
A0A087WSJ3 | A0A087WSJ3_MOUSE | 2510002D24Rik | 49 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK153794 EMBL· GenBank· DDBJ | BAE32185.1 EMBL· GenBank· DDBJ | mRNA |