Q3U573 · Q3U573_MOUSE

  • Protein
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
  • Gene
    Stt3a
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentoligosaccharyltransferase complex
Molecular Functiondolichyl-diphosphooligosaccharide-protein glycotransferase activity
Molecular Functionmetal ion binding
Biological Processco-translational protein modification
Biological Processprotein N-linked glycosylation via asparagine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
  • EC number

Gene names

    • Name
      Stt3a
    • Synonyms
      Itm1

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • C57BL/6J
    • NOD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3U573

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-41Helical
Transmembrane83-103Helical
Transmembrane115-135Helical
Transmembrane141-159Helical
Transmembrane171-196Helical
Transmembrane202-225Helical
Transmembrane237-256Helical
Transmembrane268-286Helical
Transmembrane298-319Helical
Transmembrane360-379Helical
Transmembrane410-430Helical
Transmembrane451-473Helical

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-417Oligosaccharyl transferase STT3 N-terminal
Domain512-580AglB-like core

Sequence similarities

Belongs to the STT3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    705
  • Mass (Da)
    80,598
  • Last updated
    2005-10-11 v1
  • Checksum
    CD1D796D0479F321
MTKLGFLRLSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRTTRFLAEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFFHITIDIRNVCVFLAPLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPGYISRSVAGSYDNEGIAIFCMLLTYYMWIKAVKTGSIYWAAKCALAYFYMVSSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAYCTVYCLGTILSMQISFVGFQPVLSSEHMAAFGVFGLCQIHAFVDYLRSKLNPQQFEVLFRSVISLVGFVLLTVGALLMLTGKISPWTGRFYSLLDPSYAKNNIPIIASVSEHQPTTWSSYYFDLQLLVFMFPVGLYYCFSNLSDARIFIIMYGVTSMYFSAVMVRLMLVLAPVMCILSGIGVSQVLSTYMKNLDISRPDKKSKKQQDSTYPIKNEVASGMILVMAFFLITYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWMVRIGGSTETGRHIKENDYYTPTGEFRVDREGSPVLLNCLMYKMCYYRFGQVYTEAKRPPGFDRVRNAEIGNKDFELDVLEEAYTTEHWLVRIYKVKDLDNRGLSRT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK152242
EMBL· GenBank· DDBJ
BAE31065.1
EMBL· GenBank· DDBJ
mRNA
AK153840
EMBL· GenBank· DDBJ
BAE32207.1
EMBL· GenBank· DDBJ
mRNA
AK169669
EMBL· GenBank· DDBJ
BAE41290.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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