Q3U4F9 · Q3U4F9_MOUSE
- ProteinMacrophage colony-stimulating factor 1
- GeneCsf1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids552 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | membrane | |
Molecular Function | cytokine activity | |
Molecular Function | growth factor activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | inflammatory response | |
Biological Process | innate immune response | |
Biological Process | osteoclast differentiation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMacrophage colony-stimulating factor 1
- Short namesCSF-1 ; MCSF
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3U4F9
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 494-515 | Helical | ||||
Sequence: VFHLLVPGIILVLLTVGGLLFY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-32 | |||||
Sequence: MTARGAAGRCPSSTWLGSRLLLVCLLMSRSIA | ||||||
Chain | PRO_5004229789 | 33-552 | Macrophage colony-stimulating factor 1 | |||
Sequence: KEVSEHCSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKCSSRDVVTKPDCNCLYPKATPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELPLRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDILESSLGTNWVLEEASGEASEGFLTQEAKFSPSTPVGGSIQAETDRPRALSASPFPKSTEDQKPVDITDRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSNSATPVAQLLLPKSHSWGIVLPLGELEGKRSTRDRRSPAELEGGSASEGAARPVARFNSIPLTDTGHVEQHEGSSDPQIPESVFHLLVPGIILVLLTVGGLLFYKWKWRSHRNPQTLDSSVGRPEDSSLTQDEDRQVELPV | ||||||
Disulfide bond | 39↔122 | |||||
Sequence: CSHMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSC | ||||||
Disulfide bond | 63 | Interchain | ||||
Sequence: C | ||||||
Disulfide bond | 80↔171 | |||||
Sequence: CYLKKAFFLVQDIIDETMRFKDNTPNANATERLQELSNNLNSCFTKDYEEQNKACVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNC | ||||||
Disulfide bond | 134↔178 | |||||
Sequence: CVRTFHETPLQLLEKIKNFFNETKNLLEKDWNIFTKNCNNSFAKC | ||||||
Disulfide bond | 189 | Interchain | ||||
Sequence: C | ||||||
Disulfide bond | 191 | Interchain | ||||
Sequence: C |
Keywords
- PTM
Interaction
Subunit
Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 197-293 | Disordered | ||||
Sequence: TPSSDPASASPHQPPAPSMAPLAGLAWDDSQRTEGSSLLPSELPLRIEDPGSAKQRPPRSTCQTLESTEQPNHGDRLTEDSQPHPSAGGPVPGVEDI | ||||||
Compositional bias | 252-267 | Polar residues | ||||
Sequence: RPPRSTCQTLESTEQP | ||||||
Region | 321-412 | Disordered | ||||
Sequence: KFSPSTPVGGSIQAETDRPRALSASPFPKSTEDQKPVDITDRPLTEVNPMRPIGQTQNNTPEKTDGTSTLREDHQEPGSPHIATPNPQRVSN | ||||||
Compositional bias | 370-385 | Polar residues | ||||
Sequence: MRPIGQTQNNTPEKTD | ||||||
Region | 439-465 | Disordered | ||||
Sequence: GKRSTRDRRSPAELEGGSASEGAARPV | ||||||
Region | 525-552 | Disordered | ||||
Sequence: PQTLDSSVGRPEDSSLTQDEDRQVELPV | ||||||
Compositional bias | 538-552 | Basic and acidic residues | ||||
Sequence: SSLTQDEDRQVELPV |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length552
- Mass (Da)60,648
- Last updated2005-10-11 v1
- Checksum3886D72D7A47DAAF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 252-267 | Polar residues | ||||
Sequence: RPPRSTCQTLESTEQP | ||||||
Compositional bias | 370-385 | Polar residues | ||||
Sequence: MRPIGQTQNNTPEKTD | ||||||
Compositional bias | 538-552 | Basic and acidic residues | ||||
Sequence: SSLTQDEDRQVELPV |