Q3U454 · Q3U454_MOUSE
- ProteinEGF-like domain-containing protein
- GeneLrp1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1457 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for Q3U454
Loss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions.
- AnnotationLoss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 16971
Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.
- AnnotationLow-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.
- CategoryFunction
- SourceGeneRif: 16971
Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation.
- AnnotationPeripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation.
- CategoriesFunction, Interaction
- SourceGeneRif: 16971
FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
- AnnotationFUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
- CategoryFunction
LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II-mediated signaling.
- AnnotationLRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II-mediated signaling.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 16971
Endothelial LRP1-ICD Accelerates Cognition-Associated Alpha-Synuclein Pathology and Neurodegeneration through PARP1 Activation in a Mouse Model of Parkinson's Disease.
- AnnotationEndothelial LRP1-ICD Accelerates Cognition-Associated Alpha-Synuclein Pathology and Neurodegeneration through PARP1 Activation in a Mouse Model of Parkinson's Disease.
- CategoryFunction
- SourceGeneRif: 16971
Autosomal recessive LRP1-related syndrome featuring cardiopulmonary dysfunction, bone dysmorphology, and corneal clouding.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 96828
LRP1 is a neuronal receptor for alpha-synuclein uptake and spread.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 96828
Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice.
- AnnotationActivation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice.
- CategoryFunction
- SourceGeneRif: 16971
Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1.
- AnnotationOropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1.
- CategoryFunction
- SourceGeneRif: 16971
Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91.
- AnnotationExtracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91.
- CategoryFunction
LRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling.
- AnnotationLRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling.
- CategoryFunction
Second Heart Field-Derived Cells Contribute to Angiotensin II-Mediated Ascending Aortopathies.
- CategoriesFunction, Expression
- SourceMGI: 96828
A Soluble PrP<sup>C</sup> Derivative and Membrane-Anchored PrP<sup>C</sup> in Extracellular Vesicles Attenuate Innate Immunity by Engaging the NMDA- R/LRP1 Receptor Complex.
- CategoriesFunction, Subcellular Location
- SourceMGI: 96828
Lrp1 is a host entry factor for Rift Valley fever virus.
- AnnotationLrp1 is a host entry factor for Rift Valley fever virus.
- CategoryFunction
Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity.
- AnnotationSerum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity.
- CategoryFunction
Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin.
- AnnotationEndothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin.
- CategoriesFunction, Expression
- SourceGeneRif: 16971
Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.
- AnnotationEndocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 16971
CD91 Derived Treg Epitope Modulates Regulatory T Lymphocyte Response, Regulates Expression of Costimulatory Molecules on Antigen-Presenting Cells, and Rescues Pregnancy in Mouse Pregnancy Loss Model.
- AnnotationCD91 Derived Treg Epitope Modulates Regulatory T Lymphocyte Response Regulates Expression of Costimulatory Molecules on Antigen-Presenting Cells and Rescues Pregnancy in Mouse Pregnancy Loss Model.
- CategoryFunction
- SourceGeneRif: 16971
Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue.
- AnnotationLow-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue.
- CategoryFunction
- SourceGeneRif: 16971