Q3U454 · Q3U454_MOUSE
- ProteinEGF-like domain-containing protein
- GeneLrp1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1457 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Biological Process | endocytosis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEGF-like domain-containing protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3U454
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 27↔39 | |||||
Sequence: CPSDRFKCENNRC | ||||||
Disulfide bond | 34↔52 | |||||
Sequence: CENNRCIPNRWLCDGDNDC | ||||||
Disulfide bond | 68↔80 | |||||
Sequence: CPPNQFSCASGRC | ||||||
Disulfide bond | 75↔93 | |||||
Sequence: CASGRCIPISWTCDLDDDC | ||||||
Disulfide bond | 116↔134 | |||||
Sequence: CNNGRCININWRCDNDNDC | ||||||
Disulfide bond | 128↔143 | |||||
Sequence: CDNDNDCGDNSDEAGC | ||||||
Disulfide bond | 147↔159 | |||||
Sequence: CSSTQFKCNSGRC | ||||||
Disulfide bond | 154↔172 | |||||
Sequence: CNSGRCIPEHWTCDGDNDC | ||||||
Disulfide bond | 214↔229 | |||||
Sequence: CDGDTDCMDSSDEKSC | ||||||
Disulfide bond | 257↔272 | |||||
Sequence: CDGDSDCEDNSDEENC |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 316-354 | EGF-like | ||||
Sequence: QCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGSDNHTCQ | ||||||
Domain | 358-394 | EGF-like | ||||
Sequence: YCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCR | ||||||
Repeat | 441-487 | LDL-receptor class B | ||||
Sequence: SALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIA | ||||||
Repeat | 488-530 | LDL-receptor class B | ||||
Sequence: GNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRD | ||||||
Repeat | 531-577 | LDL-receptor class B | ||||
Sequence: GILFWTDWDASLPRIEAASMSGAGRRTIHRETGSGGWPNGLTVDYLE | ||||||
Repeat | 578-622 | LDL-receptor class B | ||||
Sequence: KRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGE | ||||||
Domain | 671-711 | EGF-like | ||||
Sequence: PCEANGGRGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCY | ||||||
Repeat | 759-801 | LDL-receptor class B | ||||
Sequence: QRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVS | ||||||
Repeat | 802-845 | LDL-receptor class B | ||||
Sequence: RNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLR | ||||||
Repeat | 846-885 | LDL-receptor class B | ||||
Sequence: GKLYWTDGDNISMANMDGSNHTLLFSGQKGPVGLAIDFPE | ||||||
Domain | 981-1019 | EGF-like | ||||
Sequence: PCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACE | ||||||
Repeat | 1066-1108 | LDL-receptor class B | ||||
Sequence: DTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIA | ||||||
Repeat | 1109-1151 | LDL-receptor class B | ||||
Sequence: GNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEK | ||||||
Repeat | 1152-1195 | LDL-receptor class B | ||||
Sequence: GYLFWTEWGHYPRIERSRLDGTERVVLVNVSISWPNGISVDYQG | ||||||
Repeat | 1196-1239 | LDL-receptor class B | ||||
Sequence: GKLYWCDARMDKIERIDLETGENREVVLSSNNMDMFSVSVFEDF | ||||||
Domain | 1290-1327 | EGF-like | ||||
Sequence: VCAVANGGCQQLCLYRGGGQRACACAHGMLAEDGASCR |
Sequence similarities
Belongs to the LDLR family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,457
- Mass (Da)161,768
- Last updated2005-10-11 v1
- Checksum67BA977DF1BA92F2
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: E | ||||||
Non-terminal residue | 1457 | |||||
Sequence: V |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK154429 EMBL· GenBank· DDBJ | BAE32580.1 EMBL· GenBank· DDBJ | mRNA |