Q3U350 · Q3U350_MOUSE
- ProteinSerine/threonine-protein kinase
- GeneUlk1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1051 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Serine/threonine-protein kinase involved in autophagy in response to starvation.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | autophagosome | |
Cellular Component | cytosol | |
Cellular Component | phagophore assembly site membrane | |
Molecular Function | ATP binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | autophagosome assembly | |
Biological Process | autophagy of mitochondrion | |
Biological Process | axon extension | |
Biological Process | negative regulation of collateral sprouting | |
Biological Process | piecemeal microautophagy of the nucleus | |
Biological Process | positive regulation of autophagy | |
Biological Process | response to starvation | |
Biological Process | reticulophagy | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3U350
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-278 | Protein kinase | ||||
Sequence: FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL | ||||||
Region | 283-323 | Disordered | ||||
Sequence: PIKKSPPVPVPSYPSSGSGSSSSSSSASHLASPPSLGEMPQ | ||||||
Compositional bias | 296-323 | Polar residues | ||||
Sequence: PSSGSGSSSSSSSASHLASPPSLGEMPQ | ||||||
Region | 335-358 | Disordered | ||||
Sequence: AGFLQGSRDSGGSSKDSCDTDDFV | ||||||
Region | 394-554 | Disordered | ||||
Sequence: GLESHGRTPSPSPTCSSSPSPSGRPGPFSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGRASPSPPSHTDGAMLARKLSLGGGRPYTPSPQVGTIPERPSWSRVPSPQGADVRVGRSPRPGSSVPEHSPRTTGLGCRLH | ||||||
Compositional bias | 435-475 | Polar residues | ||||
Sequence: PTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGR | ||||||
Region | 661-686 | Disordered | ||||
Sequence: PDLSEASPFHGQQLGSGLRPAEDTRG | ||||||
Region | 727-787 | Disordered | ||||
Sequence: APSAGFGGTLHPGARGGGASSPAPVVFTVGSPPSGATPPQSTRTRMFSVGSSSSLGSTGSS | ||||||
Compositional bias | 759-787 | Polar residues | ||||
Sequence: PSGATPPQSTRTRMFSVGSSSSLGSTGSS |
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,051
- Mass (Da)112,467
- Last updated2005-10-11 v1
- Checksum5069D0769B9FFD1A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 296-323 | Polar residues | ||||
Sequence: PSSGSGSSSSSSSASHLASPPSLGEMPQ | ||||||
Compositional bias | 435-475 | Polar residues | ||||
Sequence: PTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGR | ||||||
Compositional bias | 759-787 | Polar residues | ||||
Sequence: PSGATPPQSTRTRMFSVGSSSSLGSTGSS |