Q3U2A9 · Q3U2A9_MOUSE
- ProteinTNFR-Cys domain-containing protein
- GeneTnfrsf1b
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids474 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | tumor necrosis factor receptor activity | |
Biological Process | inflammatory response |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameTNFR-Cys domain-containing protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3U2A9
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 263-286 | Helical | ||||
Sequence: IGLIVGVTSLGLLMLGLVNCFILV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MAPAALWVALVFELQLWATG | ||||||
Chain | PRO_5004229750 | 21-474 | TNFR-Cys domain-containing protein | |||
Sequence: HTVPAQVVLTPYKPEPGYECQISQEYYDRKAQMCCAKCPPGQYVKHFCNKTSDTVCADCEASMYTQVWNQFRTCLSCSSSCSTDQVETRACTKQQNRVCACEAGRYCALKTHSGSCRQCMRLSKCGPGFGVASSRAPNGNVLCKACAPGTFSDTTSSTDVCRPHRICSILAIPGNASTDAVCAPESPTLSAIPRTLYVSQPEPTRSQPLDQEPGPSQTPSILTSLGSTPIIEQSTKGGISLPIGLIVGVTSLGLLMLGLVNCFILVQRKKKPSCLQRDAKVPHVPDEKSQDAVGLEQQHLLTTAPSSSSSSLESSASAGDRRAPPGGHPQARVMAEAQGSQEARASSRISDSSHGSHGTHVNVTCIVNVCSSSDHSSQCSSQASATVGDPDAKPSASPKDEQVPFSQEECPSQSPYETTETLQSHEKPLPLGVPDMGMKPSQAGWFDQIAVKVA | ||||||
Disulfide bond | 55↔68 | |||||
Sequence: CAKCPPGQYVKHFC | ||||||
Disulfide bond | 58↔76 | |||||
Sequence: CPPGQYVKHFCNKTSDTVC | ||||||
Disulfide bond | 79↔94 | |||||
Sequence: CEASMYTQVWNQFRTC | ||||||
Disulfide bond | 101↔119 | |||||
Sequence: CSTDQVETRACTKQQNRVC | ||||||
Disulfide bond | 121↔136 | |||||
Sequence: CEAGRYCALKTHSGSC | ||||||
Disulfide bond | 145↔163 | |||||
Sequence: CGPGFGVASSRAPNGNVLC |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, repeat, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 39-76 | TNFR-Cys | ||||
Sequence: ECQISQEYYDRKAQMCCAKCPPGQYVKHFCNKTSDTVC | ||||||
Repeat | 39-76 | TNFR-Cys | ||||
Sequence: ECQISQEYYDRKAQMCCAKCPPGQYVKHFCNKTSDTVC | ||||||
Repeat | 78-119 | TNFR-Cys | ||||
Sequence: DCEASMYTQVWNQFRTCLSCSSSCSTDQVETRACTKQQNRVC | ||||||
Domain | 78-119 | TNFR-Cys | ||||
Sequence: DCEASMYTQVWNQFRTCLSCSSSCSTDQVETRACTKQQNRVC | ||||||
Repeat | 120-163 | TNFR-Cys | ||||
Sequence: ACEAGRYCALKTHSGSCRQCMRLSKCGPGFGVASSRAPNGNVLC | ||||||
Domain | 120-163 | TNFR-Cys | ||||
Sequence: ACEAGRYCALKTHSGSCRQCMRLSKCGPGFGVASSRAPNGNVLC | ||||||
Region | 220-242 | Disordered | ||||
Sequence: QPEPTRSQPLDQEPGPSQTPSIL | ||||||
Compositional bias | 295-313 | Basic and acidic residues | ||||
Sequence: LQRDAKVPHVPDEKSQDAV | ||||||
Region | 295-314 | Disordered | ||||
Sequence: LQRDAKVPHVPDEKSQDAVG | ||||||
Compositional bias | 321-337 | Polar residues | ||||
Sequence: LTTAPSSSSSSLESSAS | ||||||
Region | 321-378 | Disordered | ||||
Sequence: LTTAPSSSSSSLESSASAGDRRAPPGGHPQARVMAEAQGSQEARASSRISDSSHGSHG | ||||||
Compositional bias | 360-378 | Polar residues | ||||
Sequence: SQEARASSRISDSSHGSHG | ||||||
Region | 397-466 | Disordered | ||||
Sequence: SQCSSQASATVGDPDAKPSASPKDEQVPFSQEECPSQSPYETTETLQSHEKPLPLGVPDMGMKPSQAGWF | ||||||
Compositional bias | 420-445 | Polar residues | ||||
Sequence: DEQVPFSQEECPSQSPYETTETLQSH |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length474
- Mass (Da)50,328
- Last updated2005-10-11 v1
- ChecksumFB0412A1A54CD346
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 295-313 | Basic and acidic residues | ||||
Sequence: LQRDAKVPHVPDEKSQDAV | ||||||
Compositional bias | 321-337 | Polar residues | ||||
Sequence: LTTAPSSSSSSLESSAS | ||||||
Compositional bias | 360-378 | Polar residues | ||||
Sequence: SQEARASSRISDSSHGSHG | ||||||
Compositional bias | 420-445 | Polar residues | ||||
Sequence: DEQVPFSQEECPSQSPYETTETLQSH |