Q3TZX3 · S2533_MOUSE

  • Protein
    Solute carrier family 25 member 33
  • Gene
    Slc25a33
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (By similarity).
May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity).
Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity).
Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519).
Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity).

Catalytic activity

  • UTP(in) + UDP(out) = UTP(out) + UDP(in)
  • dUTP(out) + UTP(in) = dUTP(in) + UTP(out)
  • TTP(out) + UTP(in) = TTP(in) + UTP(out)
  • TDP(out) + UTP(in) = TDP(in) + UTP(out)
  • UTP(in) + CTP(out) = UTP(out) + CTP(in)
  • CDP(out) + UTP(in) = CDP(in) + UTP(out)
  • dCTP(out) + UTP(in) = dCTP(in) + UTP(out)
  • dCDP(out) + UTP(in) = dCDP(in) + UTP(out)
  • UTP(in) + GTP(out) = UTP(out) + GTP(in)
  • UTP(in) + GDP(out) = UTP(out) + GDP(in)
  • dGTP(out) + UTP(in) = dGTP(in) + UTP(out)
  • dGDP(out) + UTP(in) = dGDP(in) + UTP(out)
  • ITP(out) + UTP(in) = ITP(in) + UTP(out)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial membrane
Cellular Componentmitochondrion
Molecular Functionpyrimidine nucleotide transmembrane transporter activity
Biological Processcellular response to insulin stimulus
Biological Processcellular response to insulin-like growth factor stimulus
Biological Processmitochondria-nucleus signaling pathway
Biological Processmitochondrial genome maintenance
Biological Processmitochondrial respiratory chain complex III assembly
Biological Processmitochondrial transcription
Biological Processmitochondrion organization
Biological Processpositive regulation of cell growth
Biological Processpositive regulation of cell population proliferation
Biological Processpyrimidine nucleotide import into mitochondrion
Biological Processpyrimidine nucleotide transport
Biological Processregulation of mitochondrial membrane potential
Biological Processregulation of oxidative phosphorylation
Biological Processregulation of reactive oxygen species biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier family 25 member 33

Gene names

    • Name
      Slc25a33

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NOD
    • Czech II
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3TZX3
  • Secondary accessions
    • Q921P8
    • Q9CYJ1

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical; Name=1
Transmembrane49-65Helical; Name=2
Transmembrane121-141Helical; Name=3
Transmembrane190-210Helical; Name=4
Transmembrane233-253Helical; Name=5
Transmembrane298-318Helical; Name=6

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002917861-320Solute carrier family 25 member 33

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat9-118Solcar 1
Repeat126-213Solcar 2
Repeat231-315Solcar 3

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    320
  • Mass (Da)
    35,064
  • Last updated
    2005-10-11 v1
  • Checksum
    39D2EB15037D2AEC
MATGTQQKENTLLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVTPGLLQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVPNSNTVHILSAGSAAFVTNTLMNPIWMVKTRMQLERKVRGCKQMNTLQCARRVYQTEGVRGFYRGLTASYAGISETIICFAIYESLKKCLKDAPIVSSTDGAEKSSSGFFGLMAAAAVSKGCASCIAYPHEVIRTRLREEGSKYRSFVQTARLVFREEGYLAFYRGLFAQLIRQIPNTAIVLSTYEFIVYLLGERA

Sequence caution

The sequence BAB30846.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict31in Ref. 1; BAB30846
Sequence conflict122in Ref. 3; AAH11293
Sequence conflict129in Ref. 1; BAB30846
Sequence conflict154in Ref. 1; BAB30846
Sequence conflict189in Ref. 1; BAB30846
Sequence conflict293in Ref. 1; BAB30846

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK017628
EMBL· GenBank· DDBJ
BAB30846.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AK157423
EMBL· GenBank· DDBJ
BAE34084.1
EMBL· GenBank· DDBJ
mRNA
AL626808
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC011293
EMBL· GenBank· DDBJ
AAH11293.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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