Q3TZX3 · S2533_MOUSE
- ProteinSolute carrier family 25 member 33
- GeneSlc25a33
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids320 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (By similarity).
May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity).
Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity).
Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519).
Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity).
May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity).
Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity).
Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:17596519).
Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity).
Catalytic activity
- UTP(in) + UDP(out) = UTP(out) + UDP(in)
- dUTP(out) + UTP(in) = dUTP(in) + UTP(out)
- TTP(out) + UTP(in) = TTP(in) + UTP(out)
- TDP(out) + UTP(in) = TDP(in) + UTP(out)
- UTP(in) + CTP(out) = UTP(out) + CTP(in)
- CDP(out) + UTP(in) = CDP(in) + UTP(out)
- dCTP(out) + UTP(in) = dCTP(in) + UTP(out)
- dCDP(out) + UTP(in) = dCDP(in) + UTP(out)
- UTP(in) + GTP(out) = UTP(out) + GTP(in)
- UTP(in) + GDP(out) = UTP(out) + GDP(in)
- dGTP(out) + UTP(in) = dGTP(in) + UTP(out)
- dGDP(out) + UTP(in) = dGDP(in) + UTP(out)
- ITP(out) + UTP(in) = ITP(in) + UTP(out)
GO annotations
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSolute carrier family 25 member 33
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TZX3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-32 | Helical; Name=1 | |||
Transmembrane | 49-65 | Helical; Name=2 | |||
Transmembrane | 121-141 | Helical; Name=3 | |||
Transmembrane | 190-210 | Helical; Name=4 | |||
Transmembrane | 233-253 | Helical; Name=5 | |||
Transmembrane | 298-318 | Helical; Name=6 | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000291786 | 1-320 | Solute carrier family 25 member 33 | ||
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 9-118 | Solcar 1 | |||
Repeat | 126-213 | Solcar 2 | |||
Repeat | 231-315 | Solcar 3 | |||
Sequence similarities
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length320
- Mass (Da)35,064
- Last updated2005-10-11 v1
- Checksum39D2EB15037D2AEC
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 31 | in Ref. 1; BAB30846 | |||
Sequence conflict | 122 | in Ref. 3; AAH11293 | |||
Sequence conflict | 129 | in Ref. 1; BAB30846 | |||
Sequence conflict | 154 | in Ref. 1; BAB30846 | |||
Sequence conflict | 189 | in Ref. 1; BAB30846 | |||
Sequence conflict | 293 | in Ref. 1; BAB30846 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK017628 EMBL· GenBank· DDBJ | BAB30846.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AK157423 EMBL· GenBank· DDBJ | BAE34084.1 EMBL· GenBank· DDBJ | mRNA | ||
AL626808 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC011293 EMBL· GenBank· DDBJ | AAH11293.1 EMBL· GenBank· DDBJ | mRNA |