We have identified ZPO2 as a negative regulator of GATA3 thus providing an alternative mechanism that results in a reduction in or perhaps even loss of GATA3 during breast cancer development.
Gata3 promotes Cd4 expression in Thpok-deficient thymocytes. Gata3 represses CD8-lineage gene expression. These findings identify Gata3 as a critical pivot of CD4-CD8 lineage differentiation.
Functional analysis of the cooperation of Foxp3 with one such partner GATA-3 provided additional evidence for a network of transcriptional regulation afforded by Foxp3 and its associates to control distinct aspects of T(reg) cell biology.
Sox4 was induced by TGF-beta and negatively regulated the transcription factor GATA-3 the master regulator of function of T helper type 2 TH2 cells by two distinct mechanisms.
show that deletion of Gata3 allowed the appearance of interferon-gamma (IFN-gamma)-producing cells in the absence of interleukin-12 (IL-12) and IFN-gamma.
The balance between Runx3 and GATA3 interactions influences the manifestation of CD4-positive T cells as either the T helper type (Th)1 or Th2 cell phenotype.
Results show that in addition to its previously recognized function in suppressing PPARgamma transcriptional activity interaction of GATA-2 and -3 with C/EBP is necessary for their ability to negatively regulate adipogenesis.
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