Q3TYD7 · Q3TYD7_MOUSE
- ProteinDNA (cytosine-5)-methyltransferase 3A
- GeneDnmt3a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids198 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q3TYD7
miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A.
- AnnotationmiR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A.
- SourceGeneRif: 13435
Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells.
- AnnotationCombined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells.
Loss of Dnmt3a increases self-renewal and resistance to pegIFN-alpha in JAK2-V617F-positive myeloproliferative neoplasms.
- AnnotationLoss of Dnmt3a increases self-renewal and resistance to pegIFN-alpha in JAK2-V617F-positive myeloproliferative neoplasms.
- SourceGeneRif: 13435
Loss of Claudin-1 incurred by DNMT aberration promotes pancreatic cancer progression.
- AnnotationLoss of Claudin-1 incurred by DNMT aberration promotes pancreatic cancer progression.
Transcriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells.
- AnnotationTranscriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells.
- SourceGeneRif: 13435
Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2- dependent genes to promote the occurrence of atrophic nonunion.
- AnnotationSuppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.
- SourceGeneRif: 13435
Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits.
- AnnotationDistinct disease mutations in DNMT3A result in a spectrum of behavioral epigenetic and transcriptional deficits.
DNMT3A-mediated epigenetic silencing of SOX17 contributes to endothelial cell migration and fibroblast activation in wound healing.
- AnnotationDNMT3A-mediated epigenetic silencing of SOX17 contributes to endothelial cell migration and fibroblast activation in wound healing.
- SourceGeneRif: 13435
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis- associated colon cancer.
- AnnotationHematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.
Bidirectional negative feedback actions of DNMT3A and miR-145 in regulating autophagy in cardiac fibroblasts and affecting myocardial fibrosis.
- AnnotationBidirectional negative feedback actions of DNMT3A and miR-145 in regulating autophagy in cardiac fibroblasts and affecting myocardial fibrosis.
- CategoriesFunction
- SourceGeneRif: 13435
DNA methyltransferase (Dnmt) silencing causes increased Cdx2 and Nanog levels in surviving embryos.
- AnnotationDNA methyltransferase (Dnmt) silencing causes increased Cdx2 and Nanog levels in surviving embryos.
- CategoriesFunction
- SourceGeneRif: 13435
DNMT3A<sup>R882H</sup> accelerates angioimmunoblastic T-cell lymphoma in mice.
- AnnotationDNMT3A[R882H] accelerates angioimmunoblastic T-cell lymphoma in mice.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 13435
Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis.
- CategoriesFunction
- SourceMGI: 1261827
Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway.
- AnnotationLoss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 13435