Q3TXG1 · Q3TXG1_MOUSE
- ProteinMitogen-activated protein kinase kinase kinase 7
- GeneMap3k7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids579 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | MAP kinase kinase kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | apoptotic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase kinase kinase 7
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TXG1
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-291 | Protein kinase | ||||
Sequence: IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYF | ||||||
Region | 301-338 | Disordered | ||||
Sequence: PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQV | ||||||
Compositional bias | 303-338 | Polar residues | ||||
Sequence: QYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQV | ||||||
Compositional bias | 354-382 | Polar residues | ||||
Sequence: KNQAKQQSESGRLSLGASRGSSVESLPPT | ||||||
Region | 354-391 | Disordered | ||||
Sequence: KNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSAD | ||||||
Compositional bias | 416-448 | Polar residues | ||||
Sequence: LTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKP | ||||||
Region | 416-466 | Disordered | ||||
Sequence: LTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSHPWTPDDSTDTNGSD | ||||||
Coiled coil | 506-537 | |||||
Sequence: YMKVQTEIALLLQRKQELVAELDQDEKDQQNT |
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length579
- Mass (Da)64,200
- Last updated2005-10-11 v1
- Checksum97C8F6F3CA3283EE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 303-338 | Polar residues | ||||
Sequence: QYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQV | ||||||
Compositional bias | 354-382 | Polar residues | ||||
Sequence: KNQAKQQSESGRLSLGASRGSSVESLPPT | ||||||
Compositional bias | 416-448 | Polar residues | ||||
Sequence: LTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKP |