Q3TSW6 · Q3TSW6_MOUSE

  • Protein
    L-selectin
  • Gene
    Sell
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for binding site.

137250100150200250300350
TypeIDPosition(s)Description
Binding site118Ca2+ (UniProtKB | ChEBI)
Binding site120Ca2+ (UniProtKB | ChEBI)
Binding site126Ca2+ (UniProtKB | ChEBI)
Binding site143Ca2+ (UniProtKB | ChEBI)
Binding site144Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functioncarbohydrate binding
Molecular Functionmetal ion binding
Biological Processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processleukocyte migration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    L-selectin

Gene names

    • Name
      Sell

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3TSW6

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane334-355Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-38
ChainPRO_500422959739-372L-selectin
Disulfide bond57↔155
Glycosylation60N-linked (GlcNAc...) asparagine
Glycosylation104N-linked (GlcNAc...) asparagine
Disulfide bond128↔147
Disulfide bond160↔171
Disulfide bond165↔180
Glycosylation177N-linked (GlcNAc...) asparagine
Disulfide bond182↔191
Disulfide bond197↔241
Disulfide bond227↔254
Disulfide bond259↔303
Disulfide bond289↔316

Keywords

PTM databases

Interaction

Subunit

Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-156C-type lectin
Domain156-192EGF-like
Domain195-256Sushi
Domain257-318Sushi

Sequence similarities

Belongs to the selectin/LECAM family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    372
  • Mass (Da)
    42,292
  • Last updated
    2005-10-11 v1
  • Checksum
    CAB3AE980E22EC16
MVFPWRCEGTYWGSRNILKLWVWTLLCCDFLIHHGTHCWTYHYSEKPMNWENARKFCKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMWTWVGTNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALCYTASCQTGSCNGRGECVETINNHTCICDAGYYGPQCQYVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQVVQCEPLEAPELGTMDCIHPLGNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQETNRSFSKIKEGDYNPLFIPVAVMVTAFSGLAFLIWLARRLKKGKKSQERMDDPY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK161754
EMBL· GenBank· DDBJ
BAE36559.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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