Q3TRK9 · Q3TRK9_MOUSE
- ProteinMonocarboxylate transporter 1
- GeneSlc16a1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids493 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- (R)-3-hydroxybutanoate(out) + H+(out) = (R)-3-hydroxybutanoate(in) + H+(in)This reaction proceeds in the forward and the backward directions.
- (S)-lactate(in) + H+(in) = (S)-lactate(out) + H+(out)This reaction proceeds in the forward and the backward directions.
- 3-methyl-2-oxobutanoate(out) + H+(out) = 3-methyl-2-oxobutanoate(in) + H+(in)
- 4-methyl-2-oxopentanoate(out) + H+(out) = 4-methyl-2-oxopentanoate(in) + H+(in)
- acetoacetate(out) + H+(out) = acetoacetate(in) + H+(in)This reaction proceeds in the forward and the backward directions.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | basolateral plasma membrane | |
Cellular Component | lateral plasma membrane | |
Molecular Function | monocarboxylic acid transmembrane transporter activity |
Names & Taxonomy
Protein names
- Recommended nameMonocarboxylate transporter 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TRK9
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Basolateral cell membrane ; Multi-pass membrane protein
Lateral cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 17-36 | Helical | ||||
Sequence: GWGWAVLVGAFISIGFSYAF | ||||||
Transmembrane | 88-105 | Helical | ||||
Sequence: VMIAGGCLSGCGLIAASF | ||||||
Transmembrane | 111-132 | Helical | ||||
Sequence: ELYLCIGVIGGLGLAFNLNPAL | ||||||
Transmembrane | 144-164 | Helical | ||||
Sequence: PLANGLAMAGSPVFLSTLAPL | ||||||
Transmembrane | 176-195 | Helical | ||||
Sequence: GSFLILGGLLLNCCVAGSLM | ||||||
Transmembrane | 256-280 | Helical | ||||
Sequence: FLLYLSGNVVMFFGLFTPLVFLSSY | ||||||
Transmembrane | 324-340 | Helical | ||||
Sequence: YFFAASVVANGVCHLLA | ||||||
Transmembrane | 346-368 | Helical | ||||
Sequence: YVGFCVYAGVFGFAFGWLSSVLF | ||||||
Transmembrane | 380-402 | Helical | ||||
Sequence: FSSAVGLVTIVECCPVLLGPPLF | ||||||
Transmembrane | 414-436 | Helical | ||||
Sequence: YTYWACGVILIIAGIYLFIGMGI |
Keywords
- Cellular component
PTM/Processing
PTM databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 19-445 | Major facilitator superfamily (MFS) profile | ||||
Sequence: GWAVLVGAFISIGFSYAFPKSITVFFKEIEVIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYLCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFDIFDWRGSFLILGGLLLNCCVAGSLMRPIGPEQVKLEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTINKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSSYGKSKDFSSEKSAFLLSILAFVDMVARPSMGLAANTKWIRPRIQYFFAASVVANGVCHLLAPLSTTYVGFCVYAGVFGFAFGWLSSVLFETLMDLIGPQRFSSAVGLVTIVECCPVLLGPPLFGRLNDMYGDYKYTYWACGVILIIAGIYLFIGMGINYRLLAKEQ | ||||||
Compositional bias | 447-472 | Basic and acidic residues | ||||
Sequence: AEEKQKREGKEDEASTDVDEKPKETM | ||||||
Region | 447-493 | Disordered | ||||
Sequence: AEEKQKREGKEDEASTDVDEKPKETMKAAQSPQQHSSGDPTEEESPV | ||||||
Compositional bias | 473-493 | Polar residues | ||||
Sequence: KAAQSPQQHSSGDPTEEESPV |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length493
- Mass (Da)53,301
- Last updated2005-10-11 v1
- Checksum856D4B7DEB3EAD7D
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 447-472 | Basic and acidic residues | ||||
Sequence: AEEKQKREGKEDEASTDVDEKPKETM | ||||||
Compositional bias | 473-493 | Polar residues | ||||
Sequence: KAAQSPQQHSSGDPTEEESPV |