Studies identified VGLL4 as a novel activator in regulating muscle regeneration at the differentiation stage which provides new insights into the YAP-independent role of VGLL4 in skeletal muscle regeneration.
Results revealed an essential role of VGLL4 in heart valve morphogenesis via regulating valvar interstitial cells proliferation and apoptosis. Furthermore its deletion resulted in progressive valve disease. These findings suggest that mutations in VGLL4 may underlie human congenital heart valve dysplasia.
VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CtBP2 and this TEAD4-VGLL4-CtBP2 ternary complex dynamically existed at the early stage of adipogenesis.
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