Q3TPZ7 · Q3TPZ7_MOUSE
- ProteinAmyloid-like protein 2
- GeneAplp2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids633 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endomembrane system | |
Cellular Component | membrane | |
Molecular Function | heparin binding | |
Molecular Function | serine-type endopeptidase inhibitor activity | |
Molecular Function | transition metal ion binding |
Keywords
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAmyloid-like protein 2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TPZ7
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-31 | |||||
Sequence: MAATGTAAAAATGKLLVLLLLGLTAPAAALA | ||||||
Chain | PRO_5004229551 | 32-633 | Amyloid-like protein 2 | |||
Sequence: GYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKRQCKSHIVIPFKCLVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGTEYVCCPQTKTVDSDSTMSKEEEEEEEDEEDEEEDYDLDKSEFPTEADLEDFTEAAADEEEEDEEEGEEVVEDRDYYYDPFKGDDYNEENPTEPSSEGTISDKEIVHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAGLQAKNLPKTERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTSSISENPVDVRVSSEESEEIPPFHPLHPFPSLSENEGSGMAEQDGGLIGAEEKVINS | ||||||
Disulfide bond | 116↔123 | |||||
Sequence: CRRDKRQC | ||||||
Disulfide bond | 149↔203 | |||||
Sequence: CQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGTEYVCC | ||||||
Disulfide bond | 160↔190 | |||||
Sequence: CEKHQRWHTLVKEACLTEGLTLYSYGMLLPC | ||||||
Disulfide bond | 174↔202 | |||||
Sequence: CLTEGLTLYSYGMLLPCGVDQFHGTEYVC |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 46-139 | GFLD subdomain | ||||
Sequence: AVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKRQCKSHIVIPFKCLVGEFV | ||||||
Domain | 46-205 | E1 | ||||
Sequence: AVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKRQCKSHIVIPFKCLVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGTEYVCCPQ | ||||||
Region | 147-205 | CuBD subdomain | ||||
Sequence: DNCQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGTEYVCCPQ | ||||||
Region | 208-297 | Disordered | ||||
Sequence: TVDSDSTMSKEEEEEEEDEEDEEEDYDLDKSEFPTEADLEDFTEAAADEEEEDEEEGEEVVEDRDYYYDPFKGDDYNEENPTEPSSEGTI | ||||||
Compositional bias | 215-238 | Acidic residues | ||||
Sequence: MSKEEEEEEEDEEDEEEDYDLDKS | ||||||
Compositional bias | 245-270 | Acidic residues | ||||
Sequence: DLEDFTEAAADEEEEDEEEGEEVVED | ||||||
Compositional bias | 271-286 | Basic and acidic residues | ||||
Sequence: RDYYYDPFKGDDYNEE | ||||||
Domain | 310-360 | BPTI/Kunitz inhibitor | ||||
Sequence: CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC | ||||||
Domain | 373-564 | E2 | ||||
Sequence: DVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAGLQAKNLPKTERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDEL | ||||||
Region | 574-633 | Disordered | ||||
Sequence: QFTSSISENPVDVRVSSEESEEIPPFHPLHPFPSLSENEGSGMAEQDGGLIGAEEKVINS |
Sequence similarities
Belongs to the APP family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length633
- Mass (Da)71,806
- Last updated2005-10-11 v1
- Checksum4B92A51441852670
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 215-238 | Acidic residues | ||||
Sequence: MSKEEEEEEEDEEDEEEDYDLDKS | ||||||
Compositional bias | 245-270 | Acidic residues | ||||
Sequence: DLEDFTEAAADEEEEDEEEGEEVVED | ||||||
Compositional bias | 271-286 | Basic and acidic residues | ||||
Sequence: RDYYYDPFKGDDYNEE | ||||||
Non-terminal residue | 633 | |||||
Sequence: S |