Q3TN68 · Q3TN68_MOUSE

  • Protein
    Sodium/hydrogen exchanger
  • Gene
    Slc9a1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Electroneutral Na+ /H+ antiporter that extrudes Na+ in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H+ ions for extracellular Na+ in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li+ and functions also as a Na+/Li+ antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentlateral plasma membrane
Molecular Functioncalmodulin binding
Molecular Functionsodium:proton antiporter activity
Biological Processregulation of pH

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/hydrogen exchanger

Gene names

    • Name
      Slc9a1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3TN68

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane136-153Helical
Transmembrane159-181Helical
Transmembrane193-220Helical
Transmembrane232-250Helical
Transmembrane262-281Helical
Transmembrane296-322Helical
Transmembrane329-346Helical
Transmembrane352-371Helical
Transmembrane392-411Helical
Transmembrane417-441Helical
Transmembrane453-472Helical
Transmembrane484-507Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Proteomic databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region40-74Disordered
Domain114-507Cation/H+ exchanger

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    549
  • Mass (Da)
    60,990
  • Last updated
    2005-10-11 v1
  • Checksum
    1E7D33BCA98FD8E1
MMLRWSGVWGFHPPRIFPSLLVVVALVGLLPVLRSHGLQHSPTASTIRGSEPPRERSIGDVTTAPSEPLHRPDDHNLTNLIIEHGGKPSRKAFPVLDIDYPHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHH

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue549

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK165501
EMBL· GenBank· DDBJ
BAE38221.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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