Q3TN68 · Q3TN68_MOUSE
- ProteinSodium/hydrogen exchanger
- GeneSlc9a1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids549 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Electroneutral Na+ /H+ antiporter that extrudes Na+ in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H+ ions for extracellular Na+ in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li+ and functions also as a Na+/Li+ antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs.
Catalytic activity
- Li+(out) + H+(in) = Li+(in) + H+(out)
- Na+(in) + H+(out) = Na+(out) + H+(in)
- Li+(in) + Na+(out) = Li+(out) + Na+(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Cellular Component | lateral plasma membrane | |
Molecular Function | calmodulin binding | |
Molecular Function | sodium:proton antiporter activity | |
Biological Process | regulation of pH |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium/hydrogen exchanger
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TN68
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Basolateral cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 136-153 | Helical | ||||
Sequence: SCLLIVVGLLVGGLIKGV | ||||||
Transmembrane | 159-181 | Helical | ||||
Sequence: FLQSDVFFLFLLPPIILDAGYFL | ||||||
Transmembrane | 193-220 | Helical | ||||
Sequence: ILIFAVVGTLWNAFFLGGLLYAVCLVGG | ||||||
Transmembrane | 232-250 | Helical | ||||
Sequence: LLFGSIISAVDPVAVLAVF | ||||||
Transmembrane | 262-281 | Helical | ||||
Sequence: LVFGESLLNDAVTVVLYHLF | ||||||
Transmembrane | 296-322 | Helical | ||||
Sequence: FLGFLSFFVVALGGVFVGVVYGVIAAF | ||||||
Transmembrane | 329-346 | Helical | ||||
Sequence: HIRVIEPLFVFLYSYMAY | ||||||
Transmembrane | 352-371 | Helical | ||||
Sequence: FHLSGIMALIASGVVMRPYV | ||||||
Transmembrane | 392-411 | Helical | ||||
Sequence: SVSETLIFIFLGVSTVAGSH | ||||||
Transmembrane | 417-441 | Helical | ||||
Sequence: FVISTLLFCLIARVLGVLVLTWFIN | ||||||
Transmembrane | 453-472 | Helical | ||||
Sequence: QFIIAYGGLRGAIAFSLGYL | ||||||
Transmembrane | 484-507 | Helical | ||||
Sequence: FLTAIITVIFFTVFVQGMTIRPLV |
Keywords
- Cellular component
PTM/Processing
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 40-74 | Disordered | ||||
Sequence: HSPTASTIRGSEPPRERSIGDVTTAPSEPLHRPDD | ||||||
Domain | 114-507 | Cation/H+ exchanger | ||||
Sequence: LLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLV |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length549
- Mass (Da)60,990
- Last updated2005-10-11 v1
- Checksum1E7D33BCA98FD8E1
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 549 | |||||
Sequence: H |