Q3TKA0 · Q3TKA0_MOUSE
- ProteinGlucosamine-6-phosphate isomerase
- GeneGnpda1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids211 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo.
Catalytic activity
- alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4+This reaction proceeds in the forward and the backward directions.
Pathway
Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | glucosamine-6-phosphate deaminase activity | |
Molecular Function | isomerase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | N-acetylglucosamine metabolic process | |
Biological Process | UDP-N-acetylglucosamine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucosamine-6-phosphate isomerase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TKA0
Organism-specific databases
Subcellular Location
PTM/Processing
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-154 | Glucosamine/galactosamine-6-phosphate isomerase | |||
Sequence similarities
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length211
- Mass (Da)23,478
- Last updated2005-10-11 v1
- MD5 ChecksumCC06D73135C533F5178F4968F537F8A0
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK167088 EMBL· GenBank· DDBJ | BAE39245.1 EMBL· GenBank· DDBJ | mRNA |