Q3TJ51 · Q3TJ51_MOUSE

  • Protein
    Isocitrate dehydrogenase [NADP]
  • Gene
    Idh1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mg2+ or Mn2+ ion per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, site.

141450100150200250300350400
Type
IDPosition(s)Description
Binding site75-77NADP+ (UniProtKB | ChEBI)
Binding site77D-threo-isocitrate (UniProtKB | ChEBI)
Binding site82NADP+ (UniProtKB | ChEBI)
Binding site94-100D-threo-isocitrate (UniProtKB | ChEBI)
Binding site109D-threo-isocitrate (UniProtKB | ChEBI)
Binding site132D-threo-isocitrate (UniProtKB | ChEBI)
Site139Critical for catalysis
Site212Critical for catalysis
Binding site252Mn2+ (UniProtKB | ChEBI)
Binding site260NADP+ (UniProtKB | ChEBI)
Binding site275Mn2+ (UniProtKB | ChEBI)
Binding site310-315NADP+ (UniProtKB | ChEBI)
Binding site328NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionisocitrate dehydrogenase (NADP+) activity
Molecular Functionmagnesium ion binding
Molecular FunctionNAD binding
Biological Processglyoxylate cycle
Biological Processisocitrate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isocitrate dehydrogenase [NADP]
  • EC number

Gene names

    • Name
      Idh1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q3TJ51

Organism-specific databases

PTM/Processing

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-401Isopropylmalate dehydrogenase-like

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    414
  • Mass (Da)
    46,674
  • Last updated
    2005-10-11 v1
  • Checksum
    3CA44545473F841D
MSRKIKGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK167583
EMBL· GenBank· DDBJ
BAE39644.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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