Q3TGP5 · Q3TGP5_MOUSE
- ProteinHelicase ATP-binding domain-containing protein
- GeneIfih1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids549 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for Q3TGP5
The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner.
- AnnotationThe IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner.
- CategoryFunction
- SourceGeneRif: 71586
Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity.
- CategoryFunction
- SourceMGI: 1918836
Genetic determinants of micronucleus formation in vivo.
- CategoryFunction
- SourceMGI: 1918836
Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes.
- CategoryFunction
- SourceMGI: 1918836
ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.
- AnnotationADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.
- CategoryFunction
MDA5 Enhances Invasive Candida albicans Infection by Regulating Macrophage Apoptosis and Phagocytosis/Killing Functions.
- AnnotationMDA5 Enhances Invasive Candida albicans Infection by Regulating Macrophage Apoptosis and Phagocytosis/Killing Functions.
- CategoryFunction
- SourceGeneRif: 71586
MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival.
- AnnotationMDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival.
- CategoryFunction
- SourceGeneRif: 71586
Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection.
- AnnotationLong noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection.
- CategoryFunction
- SourceGeneRif: 71586
Theilovirus 3C Protease Cleaves the C-Terminal Domain of the Innate Immune RNA Sensor, Melanoma Differentiation-Associated Gene 5, and Impairs Double- Stranded RNA-Mediated IFN Response.
- AnnotationTheilovirus 3C Protease Cleaves the C-Terminal Domain of the Innate Immune RNA Sensor Melanoma Differentiation-Associated Gene 5 and Impairs Double-Stranded RNA-Mediated IFN Response.
- CategoryFunction
- SourceGeneRif: 71586
MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance.
- CategoryFunction
- SourceMGI: 1918836
Adenosine deaminase acting on RNA-1 is essential for early B lymphopoiesis.
- CategoryFunction
- SourceMGI: 1918836
A Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics.
- AnnotationA Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics.
- CategoriesFunction, Interaction
- SourceGeneRif: 71586
Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model.
- AnnotationAttenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model.
- CategoriesFunction, Phenotypes & Variants
ADAR1 mutation causes ZBP1-dependent immunopathology.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1918836
Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis.
- CategoryPhenotypes & Variants
- SourceMGI: 1918836
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway.
- AnnotationADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway.
- CategoryFunction
Antimicrobial immunity impedes CNS vascular repair following brain injury.
- CategoryFunction
- SourceMGI: 1918836
Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis.
- AnnotationHepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis.
- CategoryExpression
- SourceGeneRif: 71586