Q3TG86 · Q3TG86_MOUSE
- Proteinsteroid 11beta-monooxygenase
- GeneCyp11b1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids501 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- 21-hydroxyprogesterone + 2 H+ + O2 + 2 reduced [adrenodoxin] = 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]This reaction proceeds in the forward direction.
- 21-hydroxyprogesterone + 2 H+ + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]This reaction proceeds in the forward direction.
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Molecular Function | corticosterone 18-monooxygenase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | steroid 11-beta-monooxygenase activity | |
Molecular Function | steroid binding | |
Biological Process | aldosterone biosynthetic process | |
Biological Process | cellular response to peptide hormone stimulus | |
Biological Process | cholesterol metabolic process | |
Biological Process | cortisol biosynthetic process | |
Biological Process | cortisol metabolic process | |
Biological Process | glucocorticoid biosynthetic process | |
Biological Process | steroid biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namesteroid 11beta-monooxygenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TG86
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length501
- Mass (Da)57,747
- Last updated2005-10-11 v1
- Checksum9E1F5386BF18FBA1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC139248 EMBL· GenBank· DDBJ | AAI39249.1 EMBL· GenBank· DDBJ | mRNA | ||
BC139250 EMBL· GenBank· DDBJ | AAI39251.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168839 EMBL· GenBank· DDBJ | BAE40662.1 EMBL· GenBank· DDBJ | mRNA |