Q3TC66 · Q3TC66_MOUSE
- ProteinSerine/threonine-protein kinase RIO3
- GeneRiok3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids519 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | innate immune response | |
Biological Process | ribosome biogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase RIO3
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TC66
Organism-specific databases
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 122-159 | Disordered | ||||
Sequence: FEDSDSSEDEVDWQDTRDDPYRPAKPIPTPKKGFIGKG | ||||||
Domain | 222-470 | RIO kinase | ||||
Sequence: EKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSLEDEKEDGKAIPTECAIKVFKTTLYEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLTRMQKAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLSNEEMKDAYYQTLHLMQQLYNECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVTEALNERELFNAVSG |
Sequence similarities
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length519
- Mass (Da)58,753
- Last updated2005-10-11 v1
- ChecksumCF2DD9B2F9C772AE