Q3TBL6 · TP8L3_MOUSE
- ProteinTumor necrosis factor alpha-induced protein 8-like protein 3
- GeneTnfaip8l3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids204 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | phosphatidylinositol binding | |
Molecular Function | phosphatidylinositol transfer activity | |
Biological Process | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process | |
Biological Process | phospholipid transport | |
Biological Process | positive regulation of ERK1 and ERK2 cascade | |
Biological Process | regulation of apoptotic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTumor necrosis factor alpha-induced protein 8-like protein 3
- Short namesTNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TBL6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: On PDGF activation, translocates from cytoplasm to plasma membrane.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Deficient mice develop normally during the first 3 months of life under pathogen-free conditions. However, following subcutaneous injection of the carcinogen 3-methylcholanthrene, deficient mice exhibit markedly delayed skin tumor onset and reduced tumor size compared with wild-type mice.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 33 | Reduces binding to phosphoinositide; when associated with Gln-34; Gln-38 and Gln-42. | ||||
Sequence: K → Q | ||||||
Mutagenesis | 34 | Reduces binding to phosphoinositide; when associated with Gln-33; Gln-38 and Gln-42. | ||||
Sequence: K → Q | ||||||
Mutagenesis | 38 | Reduces binding to phosphoinositide; when associated with Gln-33; Gln-34 and Gln-42. | ||||
Sequence: K → Q | ||||||
Mutagenesis | 42 | Reduces binding to phosphoinositide; when associated with Gln-33; Gln-34 and Gln-38. | ||||
Sequence: K → Q | ||||||
Mutagenesis | 60 | Reduces binding to phosphoinositide. | ||||
Sequence: L → W | ||||||
Mutagenesis | 93 | Reduces binding to phosphoinositide; when associated with Gln-109. | ||||
Sequence: R → Q | ||||||
Mutagenesis | 109 | Reduces binding to phosphoinositide; when associated with Gln-93. | ||||
Sequence: R → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000331425 | 1-204 | Tumor necrosis factor alpha-induced protein 8-like protein 3 | |||
Sequence: MDSDSGEQSEGEPGTAAGPHVFSSKNLALQAQKKILSKIASKTVANMLIDDTSSEIFDELYKVTEIHTHNKKEAHKIMKDAIKVAIKIGILYRNKQFSQEEVIIVEKLRKKLNQTAMTMVSFYEVEYTFDTNVLSKLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYGPHGNCRPNLKRICEGINKLLDDKIL |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MDSDSGEQSEGEPGTAAGPH | ||||||
Region | 21-204 | Binding to phosphoinositides | ||||
Sequence: VFSSKNLALQAQKKILSKIASKTVANMLIDDTSSEIFDELYKVTEIHTHNKKEAHKIMKDAIKVAIKIGILYRNKQFSQEEVIIVEKLRKKLNQTAMTMVSFYEVEYTFDTNVLSKLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYGPHGNCRPNLKRICEGINKLLDDKIL |
Domain
The N-terminal domain (AA 2-20) is essential for its effect on cell growth and survival.
Sequence similarities
Belongs to the TNFAIP8 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length204
- Mass (Da)23,243
- Last updated2005-10-11 v1
- Checksum2A5830746A4D8AE5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK170374 EMBL· GenBank· DDBJ | BAE41754.1 EMBL· GenBank· DDBJ | mRNA | ||
AK171174 EMBL· GenBank· DDBJ | BAE42293.1 EMBL· GenBank· DDBJ | mRNA | ||
BC118003 EMBL· GenBank· DDBJ | AAI18004.1 EMBL· GenBank· DDBJ | mRNA | ||
BC119769 EMBL· GenBank· DDBJ | AAI19770.1 EMBL· GenBank· DDBJ | mRNA |