Q3TBE0 · Q3TBE0_MOUSE
- ProteinRho-associated protein kinase 1
- GeneRock1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids516 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | bleb | |
Cellular Component | centriole | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | Golgi membrane | |
Cellular Component | lamellipodium | |
Cellular Component | plasma membrane | |
Cellular Component | ruffle | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | Rho-dependent protein serine/threonine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | actomyosin structure organization | |
Biological Process | cortical actin cytoskeleton organization | |
Biological Process | embryonic morphogenesis | |
Biological Process | mitotic cytokinesis | |
Biological Process | regulation of cell junction assembly | |
Biological Process | Rho protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-associated protein kinase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ3TBE0
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 15-60 | |||||
Sequence: STLYKTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETK | ||||||
Coiled coil | 100-141 | |||||
Sequence: VSRLEETNSVLTKDIEMLRKENEELNERMRTAEEEYKLKKEE | ||||||
Domain | 111-177 | RhoBD | ||||
Sequence: TKDIEMLRKENEELNERMRTAEEEYKLKKEEEINNLKAAFEKNISTERTLKTQAVNKLAEIMNRKDF | ||||||
Coiled coil | 182-262 | |||||
Sequence: KKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRAKLLDLSDS | ||||||
Domain | 280-479 | PH | ||||
Sequence: ESRIEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEGIPKIFQILYANEGECRKDIEVEPVQQGEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIP | ||||||
Domain | 390-445 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPC | ||||||
Region | 495-516 | Disordered | ||||
Sequence: STRSTANQSFRKVVKNTSGKTS |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length516
- Mass (Da)60,232
- Last updated2005-10-11 v1
- Checksum5A6B4F280176040F