cadherin 2 (CDH2) and CDH4 cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and beta-catenins.
PTP1B is a novel physiological regulator of TrkB and enhanced BDNF/TrkB signaling may contribute to the beneficial metabolic effects of PTP1B deficiency
Data show that Grb14 inhibits the activity of PTP1B in retina in a phosphorylation-regulated manner and that rhodopsin-regulated Src kinase activation in retina leads to the phosphorylation of Grb14.
IL-4 induces PTP1B mRNA expression in a phosphatidylinositol 3-kinase-dependent manner and enhances PTP1B protein stability to suppress IL-4-induced STAT6 signaling.
Induction of PTP1B by hindlimb ischemia may represent an important counterregulatory mechanism that blunts overactivation of VEGFR2 during angiogenesis in vivo
These results suggest that PLCgamma1 has a key function in the regulation of growth hormone-mediated signalling by negatively regulating Jak2 activation.
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