Q3T9T6 · Q3T9T6_MOUSE
- ProteinRibonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
- GeneRnasel
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids227 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Publications for Q3T9T6
Affinity purification and characterization of (2'-5')oligo(adenylate)- dependent RNase from mouse spleen.
- CategoryInteraction
- SourceMGI: 1098272
Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action.
- CategorySequences
- SourceMGI: 1098272
Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation.
- AnnotationUnraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation.
- CategoryFunction
A novel role of RNase L in the development of nonalcoholic steatohepatitis.
- AnnotationA novel role of RNase L in the development of nonalcoholic steatohepatitis.
- CategoryFunction
Adenosine deaminase acting on RNA-1 is essential for early B lymphopoiesis.
- CategoryFunction
- SourceMGI: 1098272
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1098272
The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
- AnnotationThe function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
- CategoryFunction
The transcription factor Duxbl mediates elimination of pre-T cells that fail beta-selection.
- CategoryFunction
- SourceMGI: 1098272
Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication.
- CategoryFunction
- SourceMGI: 1098272
A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA.
- AnnotationPref-1 mRNA is a novel substrate of RNase-L.
- CategoriesFunction, Expression
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.
- CategoryFunction
- SourceMGI: 1098272
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
- AnnotationThus activation of RNase L does not require mouse hepatitis virus virus-induced interferon but rather correlates with adequate levels of basal Oas gene expression maintained by basal interferon signaling.
- CategoryFunction
RNase L is a negative regulator of cell migration.
- AnnotationRNAse L stimulates fibroblast migration.
- CategoryFunction
- SourceGeneRif: 24014
RNase L activates the NLRP3 inflammasome during viral infections.
- AnnotationThus RNA cleavage events catalyzed by RNase L are required for optimal inflammasome activation during viral infections.
- CategoryFunction
RNase L contributes to experimentally induced type 1 diabetes onset in mice.
- AnnotationData indicate that deficiency of 2-5A-dependent RNase L (RNase L) in resulted in a significant delay of diabetes onset.
- CategoryFunction
Lack of RNase L attenuates macrophage functions.
- AnnotationRNase L contributes to innate immunity through regulating macrophage functions.
- CategoryFunction
Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling.
- AnnotationThese studies highlight novel roles of RNase L in cigarette smoke plus virus induced inflammation tissue remodeling apoptosis and cytokine elaboration
- CategoryFunction
Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.
- CategoryFunction
- SourceMGI: 1098272
Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L.
- AnnotationBy targeting the effector enzyme of this antiviral pathway L* potently inhibits RNase L underscoring the importance of this enzyme in innate immunity against Theiler's virus.
- CategoryFunction
Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.
- AnnotationThe results suggest that RNase L is not an evolutionarily-conserved host defense mechanism to counteract retroviruses in vivo.
- CategoryFunction
Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.
- AnnotationRNase L activation during mouse hepatitis virus infection is cell type specific and correlates with relatively high levels of expression of oligoadenylate synthetase genes which are necessary for an effective RNase L antiviral response.
- CategoryFunction
RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.
- AnnotationRNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.
- CategoryExpression