Q3T8Z9 · Q3T8Z9_DROSE

Function

function

Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell junction
Cellular Componentphagophore assembly site membrane
Biological Processcellular response to oxidative stress
Biological Processcellular response to starvation
Biological Processglycophagy
Biological Processintestinal epithelial structure maintenance
Biological Processlarval midgut cell programmed cell death
Biological Processlipid transport
Biological Processnegative regulation of TOR signaling
Biological Processpositive regulation of JNK cascade

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 9

Gene names

    • Name
      atg9

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q3T8Z9

Subcellular Location

Membrane
; Multi-pass membrane protein
Preautophagosomal structure membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane110-135Helical
Transmembrane170-190Helical
Transmembrane335-360Helical
Transmembrane418-441Helical
Transmembrane453-471Helical
Transmembrane519-540Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-75Disordered
Compositional bias51-71Basic and acidic residues
Compositional bias789-807Basic and acidic residues
Region789-846Disordered
Compositional bias824-846Polar residues

Sequence similarities

Belongs to the ATG9 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    846
  • Mass (Da)
    95,475
  • Last updated
    2005-10-11 v1
  • Checksum
    A29A8BB3BF4DA671
MSSPHINYRSLAEEAASPFLEHHPSTGQGPSKTQDAKANAAAAHLDPLGEHGLEQPLDEHDTEHEGEDTPRNSGVMIHMVPETGRARWNHIEDLDSFFSRMYQYQQKHGFTVIVVDEMLQVLEFGFVVWLLAFVMHCVRFDVLFGDTPPGGPNPNKTTLSDVMYPTGECLANFTWVTYLVVFIAAIYLGIRLLKMVYHITQYADIRRFYNSALHIEDSDLDNFTWHEVQQRIRRVQAEQHMVPSTRSRSRNWTSITEVLRFKNYLVALMNKQLLPVRFHIPLYGEVVSLSRGMLFNIDFILFRGPGSPFQNNWQLRDEFAVRSNQTELAQRLSKLILGVALLNLVLAPVIFVWQLIYFSFSYANILRKEPGALGLRTWSNYGRLYLRHFNELDHELDARLNRAYDYADRYLNSFFSPLAAVIAKNLLFISGGLLLLILALGIYEEHVFQVEHLLVILAGLGAIGVVCRTLIPDENLVWCPEQLMTAILAHVHYLPSEWRQQAHTTKVRQEFSNFFQFKAGYLLSEIFSPFVTPFVLIFVFRPKAIELVRFFRTFTVSVRGVGNVCSFAQMDVRKHGNPDWQLTSELEEMTRATAQQPQQEPQQQSLAGGKTEMSLLRFTLNNPEWQMPKEAKQFLRGVREHAVGELVQAKTSMVQENPLTNSLISFGTMGADYCSIANSVLTAQVTPHQLEISQSLRPGLGPVSGGFPVAASDFRQMLQQNLSASVGPLDSMRRLRLSRAEGRLEGPTDTLLYGLCGVDPRVGSTPLNVGVADMCLSALYLHELNQQKRQARQSRIDEAEDERPGPSHWPPRQPAAPSAAAGSGSRHTVITSKAAESTPLLGSIRS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias51-71Basic and acidic residues
Compositional bias789-807Basic and acidic residues
Compositional bias824-846Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM085504
EMBL· GenBank· DDBJ
CAJ30202.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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