Q3T1J2 · MBOA2_RAT

  • Protein
    Lysophospholipid acyltransferase 2
  • Gene
    Mboat2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. May catalyze preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Prefers oleoyl-CoA as the acyl donor (By similarity).
May be involved in chondrocyte differentiation (By similarity).

Catalytic activity

  • a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.23 (UniProtKB | ENZYME | Rhea)
  • a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.n7 (UniProtKB | ENZYME | Rhea)
  • a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.51 (UniProtKB | ENZYME | Rhea)
  • (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA
    This reaction proceeds in the forward direction.
  • (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
    This reaction proceeds in the forward direction.
  • a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
    This reaction proceeds in the forward direction.

Activity regulation

Partially inhibited by thimerosal.

Pathway

Lipid metabolism; phospholipid metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site341
Active site372

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmembrane
Molecular Function1-acylglycerol-3-phosphate O-acyltransferase activity
Molecular Function1-acylglycerophosphocholine O-acyltransferase activity
Molecular Function1-acylglycerophosphoethanolamine O-acyltransferase activity
Molecular Function1-acylglycerophosphoserine O-acyltransferase activity
Molecular Functionacyltransferase activity
Biological Processlipid modification
Biological Processphosphatidylcholine acyl-chain remodeling
Biological Processphosphatidylethanolamine acyl-chain remodeling
Biological Processphosphatidylserine acyl-chain remodeling
Biological Processphospholipid biosynthetic process
Biological Processregulation of chondrocyte differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysophospholipid acyltransferase 2
  • EC number
  • Short names
    LPLAT 2
  • Alternative names
    • 1-acylglycerophosphate O-acyltransferase (EC:2.3.1.51
      ) . EC:2.3.1.51 (UniProtKB | ENZYME | Rhea)
    • 1-acylglycerophosphocholine O-acyltransferase
      (EC:2.3.1.23
      ) . EC:2.3.1.23 (UniProtKB | ENZYME | Rhea)
    • 1-acylglycerophosphoethanolamine O-acyltransferase
      (EC:2.3.1.n7
      ) . EC:2.3.1.n7 (UniProtKB | ENZYME | Rhea)
    • Lysophosphatidic acid acyltransferase (LPAAT; Lyso-PA acyltransferase)
    • Lysophosphatidylcholine acyltransferase (LPCAT; Lyso-PC acyltransferase)

Gene names

    • Name
      Mboat2
    • Synonyms
      Oact2

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q3T1J2

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein
Endoplasmic reticulum

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-42Helical
Transmembrane61-81Helical
Transmembrane88-108Helical
Transmembrane184-204Helical
Transmembrane236-256Helical
Transmembrane288-305Helical
Transmembrane365-385Helical
Transmembrane415-435Helical
Transmembrane443-463Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002730221-519Lysophospholipid acyltransferase 2

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    519
  • Mass (Da)
    59,001
  • Last updated
    2007-01-23 v2
  • Checksum
    D5CAFBD16F7642B3
MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAVWFRTYLHSSKTSSFIRHVVATLLGLYLAFFCFGWYALHFLVQSGISYCIMIIAGVESMHQCCFVFALGYLSVCQITRVYIFDYGQYSADFSGPMMIITQKITSLAYEIHDGMFRKDEELTPSQRGLAVRRMPSLLEYVSYTCNFMGILAGPLCSYKDYIAFIEGRASHMAQSGENGKEEQHGKAEPSPNAAVTEKLLVCGLSLLFHLTISSMLPVEYNIDEHFQATASWPTKATYLYVSLLAARPKYYFAWTLADAINNAAGFGFRGYDKNGVARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERATFSPTVQTFFLSAIWHGVYPGYYLTFLTGVLMTLAARAVRNNFRHYFVEPPQLKLFYDIITWAATQITISYTVVPFVLLSINPSFTFYRSWYYCLHICSILVLLLLPVKKSPRKKNTEENAQPSWAKKFDERENSLGQNSFSMMNNVCNQNQDTGSRHSALTQ

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6ATL5A0A8I6ATL5_RATMboat2515
A0A8I6A8B3A0A8I6A8B3_RATMboat2487

Sequence caution

The sequence BC101889 differs from that shown. Reason: Frameshift

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR03049793
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR03054282
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR03052483
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR03050975
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR03049616
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC101889
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp