Q3T1J2 · MBOA2_RAT
- ProteinLysophospholipid acyltransferase 2
- GeneMboat2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids519 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. May catalyze preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Prefers oleoyl-CoA as the acyl donor (By similarity).
May be involved in chondrocyte differentiation (By similarity).
May be involved in chondrocyte differentiation (By similarity).
Catalytic activity
- a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoAThis reaction proceeds in the forward direction.
- (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoAThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoAThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoAThis reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoAThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoAThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoAThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoAThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoAThis reaction proceeds in the forward direction.
- a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoAThis reaction proceeds in the forward direction.
- a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoAThis reaction proceeds in the forward direction.
- 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoAThis reaction proceeds in the forward direction.
- 1-octadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoAThis reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoAThis reaction proceeds in the forward direction.
Activity regulation
Partially inhibited by thimerosal.
Pathway
Lipid metabolism; phospholipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 341 | |||||
Sequence: N | ||||||
Active site | 372 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | membrane | |
Molecular Function | 1-acylglycerol-3-phosphate O-acyltransferase activity | |
Molecular Function | 1-acylglycerophosphocholine O-acyltransferase activity | |
Molecular Function | 1-acylglycerophosphoethanolamine O-acyltransferase activity | |
Molecular Function | 1-acylglycerophosphoserine O-acyltransferase activity | |
Molecular Function | acyltransferase activity | |
Biological Process | lipid modification | |
Biological Process | phosphatidylcholine acyl-chain remodeling | |
Biological Process | phosphatidylethanolamine acyl-chain remodeling | |
Biological Process | phosphatidylserine acyl-chain remodeling | |
Biological Process | phospholipid biosynthetic process | |
Biological Process | regulation of chondrocyte differentiation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysophospholipid acyltransferase 2
- EC number
- Short namesLPLAT 2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ3T1J2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 22-42 | Helical | ||||
Sequence: PIDQVNFVVCQLFALLAAVWF | ||||||
Transmembrane | 61-81 | Helical | ||||
Sequence: TLLGLYLAFFCFGWYALHFLV | ||||||
Transmembrane | 88-108 | Helical | ||||
Sequence: CIMIIAGVESMHQCCFVFALG | ||||||
Transmembrane | 184-204 | Helical | ||||
Sequence: FMGILAGPLCSYKDYIAFIEG | ||||||
Transmembrane | 236-256 | Helical | ||||
Sequence: LLVCGLSLLFHLTISSMLPVE | ||||||
Transmembrane | 288-305 | Helical | ||||
Sequence: YFAWTLADAINNAAGFGF | ||||||
Transmembrane | 365-385 | Helical | ||||
Sequence: FFLSAIWHGVYPGYYLTFLTG | ||||||
Transmembrane | 415-435 | Helical | ||||
Sequence: IITWAATQITISYTVVPFVLL | ||||||
Transmembrane | 443-463 | Helical | ||||
Sequence: FYRSWYYCLHICSILVLLLLP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000273022 | 1-519 | Lysophospholipid acyltransferase 2 | |||
Sequence: MATTSTTGSTLLQPLSNAVQLPIDQVNFVVCQLFALLAAVWFRTYLHSSKTSSFIRHVVATLLGLYLAFFCFGWYALHFLVQSGISYCIMIIAGVESMHQCCFVFALGYLSVCQITRVYIFDYGQYSADFSGPMMIITQKITSLAYEIHDGMFRKDEELTPSQRGLAVRRMPSLLEYVSYTCNFMGILAGPLCSYKDYIAFIEGRASHMAQSGENGKEEQHGKAEPSPNAAVTEKLLVCGLSLLFHLTISSMLPVEYNIDEHFQATASWPTKATYLYVSLLAARPKYYFAWTLADAINNAAGFGFRGYDKNGVARWDLISNLRIQQIEMSTSFKMFLDNWNIQTALWLKRVCYERATFSPTVQTFFLSAIWHGVYPGYYLTFLTGVLMTLAARAVRNNFRHYFVEPPQLKLFYDIITWAATQITISYTVVPFVLLSINPSFTFYRSWYYCLHICSILVLLLLPVKKSPRKKNTEENAQPSWAKKFDERENSLGQNSFSMMNNVCNQNQDTGSRHSALTQ |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length519
- Mass (Da)59,001
- Last updated2007-01-23 v2
- ChecksumD5CAFBD16F7642B3
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6ATL5 | A0A8I6ATL5_RAT | Mboat2 | 515 | ||
A0A8I6A8B3 | A0A8I6A8B3_RAT | Mboat2 | 487 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR03049793 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03054282 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03052483 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03050975 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR03049616 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC101889 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |