Q3SH14 · Q3SH14_THIDA
- ProteinGlucose-6-phosphate 1-dehydrogenase
- Genezwf
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids496 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Catalytic activity
- D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 54 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 96-97 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 155 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 185 | substrate | |||
Binding site | 189 | substrate | |||
Binding site | 223 | substrate | |||
Binding site | 242 | substrate | |||
Active site | 247 | Proton acceptor | |||
Binding site | 347 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glucose-6-phosphate dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | glucose metabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphate 1-dehydrogenase
- EC number
- Short namesG6PD
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Nitrosomonadales > Thiobacillaceae > Thiobacillus
Accessions
- Primary accessionQ3SH14
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 17-194 | Glucose-6-phosphate dehydrogenase NAD-binding | |||
Domain | 196-493 | Glucose-6-phosphate dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the glucose-6-phosphate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length496
- Mass (Da)57,010
- Last updated2005-10-11 v1
- MD5 Checksum02B6E47EAEEC69B4885FB0F3568C329F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000116 EMBL· GenBank· DDBJ | AAZ98075.1 EMBL· GenBank· DDBJ | Genomic DNA |