Q3MSQ8 · DDX4_PELLE

Function

function

Probable ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle.

Catalytic activity

Features

Showing features for binding site.

1724100200300400500600700
TypeIDPosition(s)Description
Binding site330-337ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular Componentpi-body
Cellular ComponentpiP-body
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Biological Processmale meiosis I
Biological Processmale meiotic nuclear division
Biological Processoogenesis
Biological ProcesspiRNA processing
Biological ProcesspiRNA-mediated retrotransposon silencing by heterochromatin formation
Biological Processretrotransposon silencing by piRNA-directed DNA methylation
Biological Processspermatogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable ATP-dependent RNA helicase DDX4
  • EC number
  • Alternative names
    • DEAD box protein 4
    • Vasa homolog

Gene names

    • Name
      ddx4
    • Synonyms
      vlg

Organism names

Accessions

  • Primary accession
    Q3MSQ8

Subcellular Location

Cytoplasm
Note: Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002488521-724Probable ATP-dependent RNA helicase DDX4

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif, domain.

TypeIDPosition(s)Description
Region1-25Disordered
Compositional bias37-67Polar residues
Region37-241Disordered
Compositional bias113-149Basic and acidic residues
Compositional bias162-194Polar residues
Compositional bias195-235Basic and acidic residues
Motif286-314Q motif
Domain317-500Helicase ATP-binding
Motif444-447DEAD box
Domain512-675Helicase C-terminal
Region683-724Disordered

Sequence similarities

Belongs to the DEAD box helicase family. DDX4/VASA subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    724
  • Mass (Da)
    79,780
  • Last updated
    2005-10-25 v1
  • Checksum
    99DF0C59155F512C
MSGQEDWESEIDNPPACVPNLSNSEPAFKASNQNYFSSNNAFNRTTERGFGNRKASDDCNQNFEFSERGFGKQRAGSDANQNFESSERGFGNRRGKGRGGFGTFGKDSNGKQESGDFTNDDNRTIDDNRRRGGFQRRGGFNDETSGRGRRGVRGGTSFSGFGREDGNEQSGFTSNDGFNNETSGFGSGRRGSRGDSSFSGDRESDRGRGFGRGGFRGRNEDIGVESGKGQEGFERSEQGPRVTYIPPPPPAEESDIFKHYQTGINFDKYDDIVVEVSGSDVPPAILTFEEANLCDSLAKNVCKSGYVKLTPIQKHSIPIIVAGRDLMACAQTGSGKTAAFLLPILAHLMVKGVESSAFQTLKEPEAIIVAPTRELINQIYLDARKFSYGTCVRPVVIYGGTQMFHSLKQISEGCNILCATPGRLLDVIRKEKIGLTKLRYLVLDEADRMLDMGFREDIENLLKSSGMPSKEERQTLMFSATFPSSIQSLAREILKPDYLFVVVGQVGGACSDVEQMVIEVDEFGKKDKLMEILQEIGSERTMVFVKTKKKADFIATFLCQEKVPSTSIHGDREQKERETALRDFRTGQCPVIVATSVAARGLDIENVSYVINFDIPDDIDEYVHRIGRTGRCGNTGRAISFFDKRGDDEQRIARSLVKVLSDAHQEVPAWLEEVAFSAHGSSAYNPRSNKFASTDDRKRGDSRGDYSTSGFSPSAAQAEEEDWG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias37-67Polar residues
Compositional bias113-149Basic and acidic residues
Compositional bias162-194Polar residues
Compositional bias195-235Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ841700
EMBL· GenBank· DDBJ
CAH56439.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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