Q3MSK7 · Q3MSK7_KLEPN
- Proteindihydrofolate reductase
- Genedhfr
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids160 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | dihydrofolate reductase activity | |
Molecular Function | NADP binding | |
Biological Process | dihydrofolate metabolic process | |
Biological Process | folic acid metabolic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namedihydrofolate reductase
- EC number
Gene names
Encoded on
- Plasmid 12
- Plasmid IncA/C-LS6
- Plasmid pBK30661
- Plasmid pBK30683
- Plasmid pBK31551
- Plasmid pK245
- Plasmid pK45-67VIM
- Plasmid pKDO1
- Plasmid pKP09085
- Plasmid pNDM-1saitama01
- Plasmid pRDDHA
- Plasmid pUSKPC3
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionQ3MSK7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Sequence
- Sequence statusComplete
- Length160
- Mass (Da)17,913
- Last updated2005-10-25 v1
- Checksum4DF0F5F7F9BD1473
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ449578 EMBL· GenBank· DDBJ | ABG56843.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ223605 EMBL· GenBank· DDBJ | ACI62987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX424423 EMBL· GenBank· DDBJ | AFV70416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX193301 EMBL· GenBank· DDBJ | AFZ77112.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX442976 EMBL· GenBank· DDBJ | AGO62692.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ419283 EMBL· GenBank· DDBJ | AHA87064.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ419284 EMBL· GenBank· DDBJ | AHA87072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HQ419286 EMBL· GenBank· DDBJ | AHA87096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF719970 EMBL· GenBank· DDBJ | AHG55701.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF954759 EMBL· GenBank· DDBJ | AHL67994.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF954760 EMBL· GenBank· DDBJ | AHL68160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ721789 EMBL· GenBank· DDBJ | AIT41865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB759690 EMBL· GenBank· DDBJ | BAN17422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ971342 EMBL· GenBank· DDBJ | CAJ29541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HF955507 EMBL· GenBank· DDBJ | CDF32021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MSYX01000063 EMBL· GenBank· DDBJ | OWA74561.1 EMBL· GenBank· DDBJ | Genomic DNA |