Q3MSK7 · Q3MSK7_KLEPN

  • Protein
    dihydrofolate reductase
  • Gene
    dhfr
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular Functiondihydrofolate reductase activity
Molecular FunctionNADP binding
Biological Processdihydrofolate metabolic process
Biological Processfolic acid metabolic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dihydrofolate reductase
  • EC number

Gene names

    • Name
      dhfr
    • Synonyms
      dfrA14
      , dfrA16
    • ORF names
      BV369_27260

Encoded on

  • Plasmid 12
  • Plasmid IncA/C-LS6
  • Plasmid pBK30661
  • Plasmid pBK30683
  • Plasmid pBK31551
  • Plasmid pK245
  • Plasmid pK45-67VIM
  • Plasmid pKDO1
  • Plasmid pKP09085
  • Plasmid pNDM-1saitama01
  • Plasmid pRDDHA
  • Plasmid pUSKPC3

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 12
    • RDDHA
    • NK245
    • S12
    • S15
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    Q3MSK7

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-159DHFR

Sequence similarities

Belongs to the dihydrofolate reductase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    160
  • Mass (Da)
    17,913
  • Last updated
    2005-10-25 v1
  • Checksum
    4DF0F5F7F9BD1473
MRTLKVSLMAAKAKNGVIGCGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFESMGALPNRKYAVVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGGEIYRETLPMASTLHLSTIDIEPEGDVFFPSIPNTFEVVFEQHFTSNINYCYQIWKKG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ449578
EMBL· GenBank· DDBJ
ABG56843.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ223605
EMBL· GenBank· DDBJ
ACI62987.1
EMBL· GenBank· DDBJ
Genomic DNA
JX424423
EMBL· GenBank· DDBJ
AFV70416.1
EMBL· GenBank· DDBJ
Genomic DNA
JX193301
EMBL· GenBank· DDBJ
AFZ77112.1
EMBL· GenBank· DDBJ
Genomic DNA
JX442976
EMBL· GenBank· DDBJ
AGO62692.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ419283
EMBL· GenBank· DDBJ
AHA87064.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ419284
EMBL· GenBank· DDBJ
AHA87072.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ419286
EMBL· GenBank· DDBJ
AHA87096.1
EMBL· GenBank· DDBJ
Genomic DNA
KF719970
EMBL· GenBank· DDBJ
AHG55701.1
EMBL· GenBank· DDBJ
Genomic DNA
KF954759
EMBL· GenBank· DDBJ
AHL67994.1
EMBL· GenBank· DDBJ
Genomic DNA
KF954760
EMBL· GenBank· DDBJ
AHL68160.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ721789
EMBL· GenBank· DDBJ
AIT41865.1
EMBL· GenBank· DDBJ
Genomic DNA
AB759690
EMBL· GenBank· DDBJ
BAN17422.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ971342
EMBL· GenBank· DDBJ
CAJ29541.1
EMBL· GenBank· DDBJ
Genomic DNA
HF955507
EMBL· GenBank· DDBJ
CDF32021.1
EMBL· GenBank· DDBJ
Genomic DNA
MSYX01000063
EMBL· GenBank· DDBJ
OWA74561.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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