Q3MHR2 · DCK_BOVIN

  • Protein
    Deoxycytidine kinase
  • Gene
    DCK
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site28-36ATP (UniProtKB | ChEBI)
Binding site53substrate
Binding site86substrate
Binding site97substrate
Active site127Proton acceptor
Binding site128substrate
Binding site133substrate
Binding site188-192ATP (UniProtKB | ChEBI)
Binding site197substrate
Binding site240-242ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functiondeoxyadenosine kinase activity
Molecular Functiondeoxycytidine kinase activity
Molecular Functiondeoxyguanosine kinase activity
Biological Processphosphorylation
Biological Processpyrimidine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxycytidine kinase
  • EC number
  • Short names
    dCK
  • Alternative names
    • Deoxyadenosine kinase (EC:2.7.1.76
      ) . EC:2.7.1.76 (UniProtKB | ENZYME | Rhea)
    • Deoxyguanosine kinase (EC:2.7.1.113
      ) . EC:2.7.1.113 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      DCK

Organism names

  • Taxonomic identifier
  • Strain
    • Crossbred X Angus
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    Q3MHR2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002950281-260Deoxycytidine kinase
Modified residue11Phosphoserine; by CK1
Modified residue15Phosphoserine; by CK1
Modified residue72Phosphothreonine; by CK1
Modified residue74Phosphoserine; by CK1

Post-translational modification

Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the DCK/DGK family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    260
  • Mass (Da)
    30,329
  • Last updated
    2005-10-25 v1
  • Checksum
    07EB33EA77A8F457
MATPPKRSCPSPAASSEGTRIKKISIEGNIAAGKSTFVNILKQVCEDWEVVPEPVARWCNVQSTQDEFEELTTSQKSGGNVLQMMYEKPERWSFTFQSYACLSRIRAQLAALNGKLKDAEKPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLRATPEKCLNRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKHDSLIEKVKDFLSTL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC105141
EMBL· GenBank· DDBJ
AAI05142.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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