Q3MHR2 · DCK_BOVIN
- ProteinDeoxycytidine kinase
- GeneDCK
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids260 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine.
Catalytic activity
- 2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 28-36 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GNIAAGKST | ||||||
Binding site | 53 | substrate | ||||
Sequence: E | ||||||
Binding site | 86 | substrate | ||||
Sequence: Y | ||||||
Binding site | 97 | substrate | ||||
Sequence: Q | ||||||
Active site | 127 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 128 | substrate | ||||
Sequence: R | ||||||
Binding site | 133 | substrate | ||||
Sequence: D | ||||||
Binding site | 188-192 | ATP (UniProtKB | ChEBI) | ||||
Sequence: RIYLR | ||||||
Binding site | 197 | substrate | ||||
Sequence: E | ||||||
Binding site | 240-242 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EDF |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | deoxyadenosine kinase activity | |
Molecular Function | deoxycytidine kinase activity | |
Molecular Function | deoxyguanosine kinase activity | |
Biological Process | phosphorylation | |
Biological Process | pyrimidine nucleotide metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDeoxycytidine kinase
- EC number
- Short namesdCK
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionQ3MHR2
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000295028 | 1-260 | Deoxycytidine kinase | |||
Sequence: MATPPKRSCPSPAASSEGTRIKKISIEGNIAAGKSTFVNILKQVCEDWEVVPEPVARWCNVQSTQDEFEELTTSQKSGGNVLQMMYEKPERWSFTFQSYACLSRIRAQLAALNGKLKDAEKPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLRATPEKCLNRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKHDSLIEKVKDFLSTL | ||||||
Modified residue | 11 | Phosphoserine; by CK1 | ||||
Sequence: S | ||||||
Modified residue | 15 | Phosphoserine; by CK1 | ||||
Sequence: S | ||||||
Modified residue | 72 | Phosphothreonine; by CK1 | ||||
Sequence: T | ||||||
Modified residue | 74 | Phosphoserine; by CK1 | ||||
Sequence: S |
Post-translational modification
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length260
- Mass (Da)30,329
- Last updated2005-10-25 v1
- Checksum07EB33EA77A8F457
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC105141 EMBL· GenBank· DDBJ | AAI05142.1 EMBL· GenBank· DDBJ | mRNA |