Q3KLR8 · GLYA_CHLTA

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.
Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site176(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site180-182(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site288Plays an important role in substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine biosynthetic process from serine
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • Ordered locus names
      CTA_0472

Organism names

Accessions

  • Primary accession
    Q3KLR8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002349631-497Serine hydroxymethyltransferase
Modified residue289N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    497
  • Mass (Da)
    54,271
  • Last updated
    2005-11-08 v1
  • Checksum
    BFB21D5524590DCD
MASLLDRYLRNISDKSQQNLASVAYLASLDHLLHAFPSIGQSIVQELKSQRSRLKMIASENFSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWECAETAKELFGAESAFVQPHSGADANLLAIMSIITQKIQSPAVQRLGYKTINDLPEQEYEALKAEMAQHKCLGPSLNSGGHLTHGTVRMNIMSKLMHCLPYEVNLDTELFDYDEIAKIAKEHKPTVLIAGYSSYSRRLNFATLKQIAEDCGAVLWVDMAHFAGLVAGGVFVGEENPMPYADIVTTTTHKTLRGPRGGLVLAKKEYANTLNKACPLMMGGPLPHVIAAKAIALKEAMTINFRKYAHKVVENARTLAEVFQRNGLRLLTGGTDNHMLIIDLTSLGVPGRIAEDMLTSVGIAVNRNTIPSDASGQWKTSGIRLGTPALTTLGMGSAEMEEVANIIVKVLRNITVRSNAESGSSKSEGELSEGIAQEARQRVADLLGRFPLYPEIDLETLV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000051
EMBL· GenBank· DDBJ
AAX50704.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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