Q3K2G4 · PYRDA_STRA1

Function

function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site45substrate
Binding site45-46FMN (UniProtKB | ChEBI)
Binding site69-73substrate
Binding site128FMN (UniProtKB | ChEBI)
Binding site128substrate
Active site131Nucleophile
Binding site165FMN (UniProtKB | ChEBI)
Binding site193FMN (UniProtKB | ChEBI)
Binding site194-195substrate
Binding site220FMN (UniProtKB | ChEBI)
Binding site248-249FMN (UniProtKB | ChEBI)
Binding site270-271FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondihydroorotate dehydrogenase (fumarate) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative dihydroorotate dehydrogenase A (fumarate)
  • EC number
  • Short names
    DHOD A; DHODase A; DHOdehase A

Gene names

    • Name
      pyrD
    • Ordered locus names
      SAK_0657

Organism names

Accessions

  • Primary accession
    Q3K2G4

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001002271-310Putative dihydroorotate dehydrogenase A (fumarate)

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    310
  • Mass (Da)
    34,257
  • Last updated
    2005-11-08 v1
  • Checksum
    7BEBDD482D828ED9
MVSLKTEIAGFSFDNCLMNAAGIYCMTKEELLAIENSEAGSFVTKTGTLEAREGNPQPRYADTDWGSINSMGLPNKGIDYYLDFVTELQDQDNSKNHVLSLVGLSPEETHIILKKVENSSYNGLIELNLSCPNVPGKPQIAYDFEMTDLILSEIFSYYQKPLGIKLPPYFDIVHFDQAATIFNKYPLAFINCVNSIGNGLVIDDETVVIKPKNGFGGIGGDFIKPTALANVHAFYKRLNPSIKIIGTGGVKNGRDAFEHILCGASMVQIGTALQKEGPEIFQRVSRELKEIMADKGYQSLEDFRGQLNYL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000114
EMBL· GenBank· DDBJ
ABA44965.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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