Q3JNX1 · UBIA_BURP1
- Protein4-hydroxybenzoate octaprenyltransferase
- GeneubiA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids287 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
Catalytic activity
- 4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | 4-hydroxybenzoate decaprenyltransferase activity | |
Molecular Function | 4-hydroxybenzoate nonaprenyltransferase activity | |
Molecular Function | 4-hydroxybenzoate octaprenyltransferase activity | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxybenzoate octaprenyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > pseudomallei group
Accessions
- Primary accessionQ3JNX1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 30-50 | Helical | ||||
Sequence: ALWIASDGHPAPSLVVIFALG | ||||||
Transmembrane | 92-112 | Helical | ||||
Sequence: IAIAVGLALVSFLLILPLNGL | ||||||
Transmembrane | 133-153 | Helical | ||||
Sequence: FFAIPQAYLGIAFGFGIPMAF | ||||||
Transmembrane | 158-178 | Helical | ||||
Sequence: DTVPMIAWAMLAANVFWSVAY | ||||||
Transmembrane | 207-227 | Helical | ||||
Sequence: VLAIMLCYAAMLGIYVWLGAA | ||||||
Transmembrane | 232-252 | Helical | ||||
Sequence: WPYWAGWAAAAGCSIYHYTLI | ||||||
Transmembrane | 266-286 | Helical | ||||
Sequence: HNNWLGGVLFAGIAAHYALAV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000262784 | 1-287 | 4-hydroxybenzoate octaprenyltransferase | |||
Sequence: MLARFPLYLRLIRMDKPIGSLLLLWPTLNALWIASDGHPAPSLVVIFALGTLLMRSAGCAINDYADRDFDRHVKRTAERPLTSGKIRAWEAIAIAVGLALVSFLLILPLNGLTKELSVVAVFVAATYPFMKRFFAIPQAYLGIAFGFGIPMAFAAVQDTVPMIAWAMLAANVFWSVAYDTAYAMVDRDDDLKIGMRTSAITFGRHDVLAIMLCYAAMLGIYVWLGAALHFGWPYWAGWAAAAGCSIYHYTLIKDRERMACFAAFRHNNWLGGVLFAGIAAHYALAVR |
Structure
Sequence
- Sequence statusComplete
- Length287
- Mass (Da)31,688
- Last updated2006-11-28 v2
- ChecksumDD14493085F58D33
Sequence caution
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000124 EMBL· GenBank· DDBJ | ABA47892.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |