Q3IMJ0 · HIS3_NATPD

Function

function

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site74Mg2+ (UniProtKB | ChEBI)
Binding site75Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site76Mg2+ (UniProtKB | ChEBI)
Binding site78Mg2+ (UniProtKB | ChEBI)
Binding site91Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site98Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH

Gene names

    • Name
      hisI
    • Ordered locus names
      NP_5154A

Organism names

Accessions

  • Primary accession
    Q3IMJ0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002298471-120Phosphoribosyl-AMP cyclohydrolase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PRA-CH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    120
  • Mass (Da)
    13,357
  • Last updated
    2005-11-08 v1
  • Checksum
    046A3955DE5D8BF5
MSVDLAFDEQELLPAVAQDAESGDVLMLAYVSEEAVARSRETGYAHYYSRSREELWKKGGSSGHTQEIEEIRVDCDGDAILYLVEQAGGACHTGYDTCFHRTLDGDIVGEQVFDPEEIYE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR936257
EMBL· GenBank· DDBJ
CAI50668.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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