Q3HUX0 · Q3HUX0_PIG
- Proteinlong-chain-fatty-acid--CoA ligase
- GeneSLC27A1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids646 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoAThis reaction proceeds in the forward direction.
- a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphateThis reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | plasma membrane | |
Molecular Function | fatty acid transmembrane transporter activity | |
Molecular Function | long-chain fatty acid transmembrane transporter activity | |
Molecular Function | nucleotide binding | |
Molecular Function | oleoyl-CoA ligase activity | |
Biological Process | long-chain fatty acid import into cell | |
Biological Process | long-chain fatty acid metabolic process | |
Biological Process | medium-chain fatty acid transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namelong-chain-fatty-acid--CoA ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionQ3HUX0
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-31 | |||||
Sequence: MRTPGACSASVASLVLLWLLGLPWTWSTAAA | ||||||
Chain | PRO_5015097408 | 32-646 | long-chain-fatty-acid--CoA ligase | |||
Sequence: LGVYVGGGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRARHTIPQIFQAVARQQPEHLALVDAGSGACWTFAQLDAYSNAVANLFRQLGFVPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNINLRREPLTFCLGTSGAKALVFGEELAVAVAEVSGQLGKSLVKFCSGDSRPEGLLPDTQLLDPLLKETSTAPLAQPPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYRMQATDVIYDCLPLYHSAGNIVGVGQCLIYGLTVVLRKKFSASRFWEDCVKYNCTVVQYIGEICRYLLKQPVREAEGQHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGACGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYISESATSKKIAHSVFCKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHGQLSPNALYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQHEGFDPRQTSDRLFFLDLKQGHYLPLDQSVYTRICSGAFFL |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 82-432 | AMP-dependent synthetase/ligase | ||||
Sequence: FQAVARQQPEHLALVDAGSGACWTFAQLDAYSNAVANLFRQLGFVPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNINLRREPLTFCLGTSGAKALVFGEELAVAVAEVSGQLGKSLVKFCSGDSRPEGLLPDTQLLDPLLKETSTAPLAQPPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYRMQATDVIYDCLPLYHSAGNIVGVGQCLIYGLTVVLRKKFSASRFWEDCVKYNCTVVQYIGEICRYLLKQPVREAEGQHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGACGFNSRILPHVYPIRLVKVNEDTMELL | ||||||
Domain | 523-598 | AMP-binding enzyme C-terminal | ||||
Sequence: EVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHGQLSPNALYQELQKVLAPYARPIFLRLLPQVDTTGTFK |
Sequence similarities
Belongs to the ATP-dependent AMP-binding enzyme family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length646
- Mass (Da)71,234
- Last updated2005-11-08 v1
- ChecksumF26F289F7C9571EE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ192231 EMBL· GenBank· DDBJ | ABA39831.1 EMBL· GenBank· DDBJ | mRNA | ||
DQIR01160610 EMBL· GenBank· DDBJ | HDB16087.1 EMBL· GenBank· DDBJ | Transcribed RNA | ||
GACC01000240 EMBL· GenBank· DDBJ | JAA53567.1 EMBL· GenBank· DDBJ | mRNA |