Q3EBY6 · MCAC2_ARATH
- ProteinProtein MID1-COMPLEMENTING ACTIVITY 2
- GeneMCA2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids416 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Calcium-permeable stretch-activated channel component. Probably involved in mechanosensing and in mechano-stimulated calcium uptake mechanism.
Activity regulation
Inhibited by GdCl3, but not by verapamil.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calcium channel activity | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | post-embryonic root development |
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProtein MID1-COMPLEMENTING ACTIVITY 2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ3EBY6
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 338-354 | Helical | ||||
Sequence: LIVYSLILSCCCYTCCI |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype when grown under normal conditions, due to redundancy with MCA1. The roots are able to normally sense the hardness of the growth medium. Mca1 and mca2 double mutant shows a strong growth defect.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 36 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000407742 | 1-416 | Protein MID1-COMPLEMENTING ACTIVITY 2 | |||
Sequence: MANSWDQLGEIASVAQLTGIDALKLIGMIVNAANTARMHKKNCRQFAHHLKLIRNLLEQIKNSEMNQRSEILEPLQGLDDALRRSYILVKSCQEKSYLYLLAMGWNIVNQFEKAQNEIDLFLKIVPLINMADNARIRERLEAIERDQREYTLDEEDRKVQDVILKQESTREAATSVLKKTLSRSYPNMGFCEALKTEEEKLQLELQRSRARYDADQCEVIQRLIDVTQTAATVEPNLEKVLTKKEELTSSKKRDDLYDTDSSSIRADSRSTSYVSSGHELLSGRSLQHRGNWHADLLDCCSEPCLCLKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILSCCCYTCCIRKKLRKTLNITGGCIDDFLSHLMCCCCALVQELREVEIHRASYGTEKSNKEMSPPTPQFMEE |
Proteomic databases
Expression
Tissue specificity
Expressed in roots, leaves, stems, flowers and siliques. In the root, high levels of expression in vascular tissues, in the stele and endodermis, but no expression in the cortex, epidermis, root cap, promeristem and adjacent elongation zone of the primary root. Not expressed in root hairs. Detected in shoot apical meristem, leaf mesophyll cells and vascular tissues, upper half of inflorescence, but not in petioles of rosette leaves.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q3EBY6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length416
- Mass (Da)47,414
- Last updated2005-11-08 v1
- Checksum1D9F308788EA9F42
Q3EBY6-2
- Name2
- Differences from canonical
- 398-399: Missing
Q3EBY6-3
- Name3
- Differences from canonical
- 399-416: TEKSNKEMSPPTPQFMEE → KIYTFTDILTYF
Q3EBY6-4
- Name4
- Differences from canonical
- 307-416: LKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILSCCCYTCCIRKKLRKTLNITGGCIDDFLSHLMCCCCALVQELREVEIHRASYGTEKSNKEMSPPTPQFMEE → KPSHSVFI
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8AZD6 | A0A1P8AZD6_ARATH | MCA2 | 385 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_040965 | 307-416 | in isoform 4 | |||
Sequence: LKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILSCCCYTCCIRKKLRKTLNITGGCIDDFLSHLMCCCCALVQELREVEIHRASYGTEKSNKEMSPPTPQFMEE → KPSHSVFI | ||||||
Alternative sequence | VSP_040966 | 398-399 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_040967 | 399-416 | in isoform 3 | |||
Sequence: TEKSNKEMSPPTPQFMEE → KIYTFTDILTYF |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB196961 EMBL· GenBank· DDBJ | BAF46390.1 EMBL· GenBank· DDBJ | mRNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06682.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06683.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06685.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | ANM62012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | ANM62013.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | ANM62015.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | ANM62016.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | ANM62017.1 EMBL· GenBank· DDBJ | Genomic DNA |