Q3E772 · LSO2_YEAST

Function

function

Ribosome-binding protein involved in ribosome hibernation by associating with translationally inactive ribosomes (PubMed:32687489).
Required for translational recovery after starvation from stationary phase (PubMed:30208026, PubMed:32687489).
May facilitate rapid translation reactivation by stabilizing the recycling-competent state of inactive ribosomes (PubMed:30208026, PubMed:32687489).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionribosome binding
Molecular Functiontranslation repressor activity
Biological Processcellular response to nutrient
Biological Processcytoplasmic translational elongation
Biological Processintracellular iron ion homeostasis
Biological Processribosome hibernation

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein LSO2
  • Alternative names
    • Late-annotated small open reading frame 2

Gene names

    • Name
      LSO2
    • Ordered locus names
      YGR169C-A

Organism names

Accessions

  • Primary accession
    Q3E772
  • Secondary accessions
    • D6VUV3

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Note: Under iron-replete conditions, enriched in the nucleus. Under iron-depleted conditions, expressed in both nucleus and cytoplasm.

Keywords

Phenotypes & Variants

Disruption phenotype

Mild slow-growth phenotype in response to reduced iron levels (PubMed:26450372).
Displays global translation defects during recovery from stationary phase with translation of most genes reduced more than 4-fold. Ribosomes accumulated at start codons, were depleted from stop codons, and showed codon-specific changes in occupancy (PubMed:30208026).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002453861-92Protein LSO2

Proteomic databases

PTM databases

Expression

Induction

Constitutively expressed. Expression is not regulated by iron unlike the LSO1 paralog.

Interaction

Subunit

Associates with translationally inactive ribosomes in the nonrotated state (PubMed:32687489).
LSO2 bridges the decoding sites of the small with the GTPase activating center (GAC) of the large subunit (PubMed:32687489).
This position allows accommodation of the DOM34-dependent ribosome recycling system, which splits LSO2-containing ribosomes (PubMed:32687489).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, coiled coil.

Type
IDPosition(s)Description
Region1-92Disordered
Compositional bias13-86Basic and acidic residues
Coiled coil17-80

Sequence similarities

Belongs to the CCDC124 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    92
  • Mass (Da)
    10,495
  • Last updated
    2005-11-08 v1
  • Checksum
    0B00892B34858428
MGKRFSESAAKKAAGLARKRDQAHAKQRAQMEQLEAEEASKWEQGSRKENAKKLEEEQKRQEKARAKKERDALLTAEEEQLGKGGKGKRKMK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias13-86Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z72954
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BK006941
EMBL· GenBank· DDBJ
DAA08264.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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