Q3E772 · LSO2_YEAST
- ProteinProtein LSO2
- GeneLSO2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Ribosome-binding protein involved in ribosome hibernation by associating with translationally inactive ribosomes (PubMed:32687489).
Required for translational recovery after starvation from stationary phase (PubMed:30208026, PubMed:32687489).
May facilitate rapid translation reactivation by stabilizing the recycling-competent state of inactive ribosomes (PubMed:30208026, PubMed:32687489).
Required for translational recovery after starvation from stationary phase (PubMed:30208026, PubMed:32687489).
May facilitate rapid translation reactivation by stabilizing the recycling-competent state of inactive ribosomes (PubMed:30208026, PubMed:32687489).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ribosome binding | |
Molecular Function | translation repressor activity | |
Biological Process | cellular response to nutrient | |
Biological Process | cytoplasmic translational elongation | |
Biological Process | intracellular iron ion homeostasis | |
Biological Process | ribosome hibernation |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein LSO2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ3E772
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Mild slow-growth phenotype in response to reduced iron levels (PubMed:26450372).
Displays global translation defects during recovery from stationary phase with translation of most genes reduced more than 4-fold. Ribosomes accumulated at start codons, were depleted from stop codons, and showed codon-specific changes in occupancy (PubMed:30208026).
Displays global translation defects during recovery from stationary phase with translation of most genes reduced more than 4-fold. Ribosomes accumulated at start codons, were depleted from stop codons, and showed codon-specific changes in occupancy (PubMed:30208026).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000245386 | 1-92 | Protein LSO2 | ||
Proteomic databases
PTM databases
Expression
Induction
Constitutively expressed. Expression is not regulated by iron unlike the LSO1 paralog.
Interaction
Subunit
Associates with translationally inactive ribosomes in the nonrotated state (PubMed:32687489).
LSO2 bridges the decoding sites of the small with the GTPase activating center (GAC) of the large subunit (PubMed:32687489).
This position allows accommodation of the DOM34-dependent ribosome recycling system, which splits LSO2-containing ribosomes (PubMed:32687489).
LSO2 bridges the decoding sites of the small with the GTPase activating center (GAC) of the large subunit (PubMed:32687489).
This position allows accommodation of the DOM34-dependent ribosome recycling system, which splits LSO2-containing ribosomes (PubMed:32687489).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-92 | Disordered | |||
Compositional bias | 13-86 | Basic and acidic residues | |||
Coiled coil | 17-80 | ||||
Sequence similarities
Belongs to the CCDC124 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length92
- Mass (Da)10,495
- Last updated2005-11-08 v1
- Checksum0B00892B34858428
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 13-86 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z72954 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BK006941 EMBL· GenBank· DDBJ | DAA08264.1 EMBL· GenBank· DDBJ | Genomic DNA |