Q3BCQ4 · RHCG_CANLF

Function

function

Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4+ ion with acidic residues of the pore entry followed by dissociation of NH4+ into NH3 and H+. As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4+ (By similarity).
May act as a CO2 channel providing for renal acid secretion (By similarity).

Catalytic activity

  • NH4+(in) = NH4+(out)
    This reaction proceeds in the forward
    and the backward
    directions.
  • methylamine(out) = methylamine(in)
    This reaction proceeds in the forward direction.
  • CO2(out) = CO2(in)
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentcytoplasmic vesicle
Cellular Componentplasma membrane
Molecular Functionammonium channel activity
Molecular Functioncarbon dioxide transmembrane transporter activity
Biological Processammonium homeostasis
Biological Processammonium transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ammonium transporter Rh type C
  • Alternative names
    • Rhesus blood group family type C glycoprotein (Rh family type C glycoprotein; Rh type C glycoprotein)

Gene names

    • Name
      RHCG

Organism names

Accessions

  • Primary accession
    Q3BCQ4

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Note: Also detected at the basolateral membrane and in subapical vesicles.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-9Cytoplasmic
Transmembrane10-30Helical
Topological domain31-61Extracellular
Transmembrane62-82Helical
Topological domain83-90Cytoplasmic
Transmembrane91-111Helical
Topological domain112-125Extracellular
Transmembrane126-145Helical
Topological domain146-151Cytoplasmic
Transmembrane152-174Helical
Topological domain175-179Extracellular
Transmembrane180-200Helical
Topological domain201-219Cytoplasmic
Transmembrane220-240Helical
Topological domain241-251Extracellular
Transmembrane252-272Helical
Topological domain273-285Cytoplasmic
Transmembrane286-306Helical
Topological domain307Extracellular
Transmembrane308-328Helical
Topological domain329-339Cytoplasmic
Transmembrane340-360Helical
Topological domain361-396Extracellular
Transmembrane397-417Helical
Topological domain418-460Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002835761-460Ammonium transporter Rh type C
Glycosylation48N-linked (GlcNAc...) asparagine

Post-translational modification

N-glycosylated.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    460
  • Mass (Da)
    50,799
  • Last updated
    2005-11-22 v1
  • Checksum
    11D3BB0D9BE68841
MVWNTNLRWRLPVTCLLLQVALVVLFGVFVRYDMDADPHWIDKKEAENSTSDMENEFYYRYPSFQDVHVMIFVGFGFLMTFLQRYGYSSVGFNFLLAAFGIQWALLLQGWFHSYYRGYIRVGVENLINADFCVGSVCVAFGAVLGKVSPVQLLIMTLFQVTLFSVNEFILLNLLEVKDAGGSMTIHTFGAYFGLTVTWILYRPGLHQSKERQSSVYHSDLFAMIGTLFLWMYWPSFNSAVSNHGDAQHRAAINTYCSLAACVLTSVALSSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGSLIVGFICGIVSTLGFVYLTPFLESRLRVQDTCGIHNLHGIPGIIGAIVGAVTASCANTDVYGVNGLTQAFGFDGFKTNRTPSMQGKFQAAGLFVSLAMALVGGIIVGIILKLPFWGQPADENCFEDAIYWEMPEEPKSTVLHPEDSTLKPSEP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY831678
EMBL· GenBank· DDBJ
AAX39720.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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