Q3A7A0 · Q3A7A0_SYNC1
- ProteinCobyric acid synthase
- GenecobQ
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids864 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.
Catalytic activity
- O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2
Pathway
Cofactor biosynthesis; adenosylcobalamin biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 706 | Nucleophile | |||
Active site | 803 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ABC-type vitamin B12 transporter activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | threonine-phosphate decarboxylase activity | |
Biological Process | cobalamin biosynthetic process | |
Biological Process | glutamine metabolic process | |
Biological Process | methylation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCobyric acid synthase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfuromonadia > Desulfuromonadales > Syntrophotaleaceae > Syntrophotalea
Accessions
- Primary accessionQ3A7A0
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 27-356 | Aminotransferase class I/classII large | |||
Domain | 375-600 | CobQ/CobB/MinD/ParA nucleotide binding | |||
Domain | 626-809 | CobB/CobQ-like glutamine amidotransferase | |||
Sequence similarities
Belongs to the CobB/CobQ family. CobQ subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length864
- Mass (Da)94,910
- Last updated2005-11-22 v1
- Checksum1A96C41A09CDCDC3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000142 EMBL· GenBank· DDBJ | ABA87744.1 EMBL· GenBank· DDBJ | Genomic DNA |