Q39575 · DYHG_CHLRE

Function

function

Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.

Features

Showing features for binding site.

144855001,0001,5002,0002,5003,0003,5004,000
TypeIDPosition(s)Description
Binding site1819-1826ATP (UniProtKB | ChEBI)
Binding site2099-2106ATP (UniProtKB | ChEBI)
Binding site2425-2432ATP (UniProtKB | ChEBI)
Binding site2802-2809ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxonemal dynein complex
Cellular Componentmicrotubule
Cellular Componentmotile cilium
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiondynein intermediate chain binding
Molecular Functiondynein light intermediate chain binding
Molecular Functionminus-end-directed microtubule motor activity
Biological Processcilium movement involved in cell motility
Biological Processouter dynein arm assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Dynein gamma chain, flagellar outer arm

Gene names

    • Name
      ODA2
    • Synonyms
      ODA-2

Organism names

Accessions

  • Primary accession
    Q39575

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001146501-4485Dynein gamma chain, flagellar outer arm

Interaction

Subunit

Consists of at least 3 heavy chains (alpha, beta and gamma), 2 intermediate chains and 8 light chains.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, coiled coil.

TypeIDPosition(s)Description
Region1-1780Stem
Coiled coil449-469
Coiled coil804-838
Coiled coil1093-1114
Coiled coil1275-1297
Coiled coil1699-1727
Region1781-2002AAA 1
Region2061-2279AAA 2
Region2384-2638AAA 3
Region2763-3013AAA 4
Coiled coil3077-3099
Region3077-3343Stalk
Coiled coil3196-3227
Coiled coil3265-3343
Region3412-3643AAA 5
Coiled coil3569-3663
Region3857-4071AAA 6

Domain

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

Sequence similarities

Belongs to the dynein heavy chain family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    4,485
  • Mass (Da)
    512,846
  • Last updated
    1997-11-01 v1
  • Checksum
    974B79328B403677

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U15303
EMBL· GenBank· DDBJ
AAA50455.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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