Q39445 · TBB_CICAR

Function

function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

144950100150200250300350400
TypeIDPosition(s)Description
Binding site11GTP (UniProtKB | ChEBI)
Binding site71GTP (UniProtKB | ChEBI)
Binding site71Mg2+ (UniProtKB | ChEBI)
Binding site140GTP (UniProtKB | ChEBI)
Binding site144GTP (UniProtKB | ChEBI)
Binding site145GTP (UniProtKB | ChEBI)
Binding site146GTP (UniProtKB | ChEBI)
Binding site206GTP (UniProtKB | ChEBI)
Binding site228GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Molecular Functionstructural constituent of cytoskeleton
Biological Processmicrotubule-based process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tubulin beta chain
  • Alternative names
    • Beta-tubulin

Gene names

    • Name
      TUBB

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Castellana
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > Hologalegina > IRL clade > Cicereae > Cicer

Accessions

  • Primary accession
    Q39445

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000483361-449Tubulin beta chain

Proteomic databases

Interaction

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the tubulin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    50,577
  • Last updated
    1996-11-01 v1
  • Checksum
    FC3E349166105CBA
MREILHVQGGQCGNQIGSKFWEVICDEHGIDQTGKYISEGGSDTQLERINVYYNEASGGRYVPRAVLMDLEPGTMESIRSGPFGKIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLSTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYVSLTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQIINVQNKNSSYFVEWIPNNVKSSVCDIPPKNLKMSSTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVAEYQQYQDAIAEEEDEYEEEGEEQYDEQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1S2X7K7A0A1S2X7K7_CICARTUBB449

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X98406
EMBL· GenBank· DDBJ
CAA67056.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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