Q39232 · SUC1_ARATH
- ProteinSucrose transport protein SUC1
- GeneSUC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids513 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Responsible for the transport of sucrose into the cell, with the concomitant uptake of protons (symport system). This transport is both voltage- and energy-dependent. Can also transport other glucosides such as maltose, alpha-phenylglucoside and beta-phenylglucoside. May also transport biotin. Required for normal pollen germination and anthocyanin accumulation induced by sucrose.
Catalytic activity
- sucrose(out) + H+(out) = sucrose(in) + H+(in)This reaction proceeds in the forward direction.
Activity regulation
Inhibited by DEPC, protonophores (e.g. dinitrophenol and carbonyl cyanide m-chlorophenyl-hydrazone (CCCP)), and SH group inhibitors (e.g. N-ethylmaleimide (NEM) and p-chloromercuriphenyl sulphonic acid (PCMPS)).
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
450 μM | sucrose | 5.5 | 30 |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
45 μmol/h/g | (without glucose) | ||||
154 μmol/h/g | (in the presence of 10 mM glucose) |
pH Dependence
Optimum pH is 5-6.
Pathway
Glycan biosynthesis; sucrose metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | plasma membrane | |
Cellular Component | plasmodesma | |
Cellular Component | vacuole | |
Molecular Function | sucrose:proton symporter activity | |
Biological Process | pollen germination | |
Biological Process | response to nematode | |
Biological Process | sucrose metabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSucrose transport protein SUC1
- Short namesAtSUC1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ39232
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-32 | Cytoplasmic | |||
Transmembrane | 33-53 | Helical | |||
Topological domain | 54-67 | Extracellular | |||
Transmembrane | 68-88 | Helical | |||
Topological domain | 89-101 | Cytoplasmic | |||
Transmembrane | 102-122 | Helical | |||
Topological domain | 123-139 | Extracellular | |||
Transmembrane | 140-160 | Helical | |||
Topological domain | 161-178 | Cytoplasmic | |||
Transmembrane | 179-199 | Helical | |||
Topological domain | 200-224 | Extracellular | |||
Transmembrane | 225-245 | Helical | |||
Topological domain | 246-282 | Cytoplasmic | |||
Transmembrane | 283-303 | Helical | |||
Topological domain | 304-334 | Extracellular | |||
Transmembrane | 335-355 | Helical | |||
Topological domain | 356-365 | Cytoplasmic | |||
Transmembrane | 366-386 | Helical | |||
Topological domain | 387-408 | Extracellular | |||
Transmembrane | 409-429 | Helical | |||
Topological domain | 430-441 | Cytoplasmic | |||
Transmembrane | 442-462 | Helical | |||
Topological domain | 463-474 | Extracellular | |||
Transmembrane | 475-495 | Helical | |||
Topological domain | 496-513 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Defective pollen with low rate of germination. Reduction of anthocyanin accumulation in response to exogenous sucrose or maltose.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 65 | No sucrose transport activity, high instability. | |||
Mutagenesis | 65 | Reduced sucrose transport activity. | |||
Mutagenesis | 65 | Enhanced sucrose transport activity. | |||
Mutagenesis | 65 | Reduced sensitivity to DEPC. | |||
Mutagenesis | 65 | Enhanced sucrose transport activity, reduced sensitivity to DEPC. | |||
Mutagenesis | 65 | Reduced sucrose transport activity, reduced sensitivity to DEPC. | |||
Variants
![](/variants.8e7f84.jpg)
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000122522 | 1-513 | Sucrose transport protein SUC1 | ||
Modified residue | 20 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in flowers (at protein level). Highly expressed in pollen. Expressed in pollen tubes and root vascular cylinder, pericycle and endodermis.
Induction
By exogenous sucrose in roots. Induced by sucrose depletion.
Developmental stage
Transcripts accumulate in mature pollen before and during germination, but translation starts only when pollen germination initiates, and continues in pollen tubes. Expressed in cells surrounding the vascular bundle of the anther connective tissue, mostly at the dehiscence time. Also present in a ring of parenchymatic cells between the xylem vessels of the style (upper end of the transmitting tract toward which pollen tubes grow). Expressed in the epidermal cell layers of funiculi (at protein level).
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-11 | Basic and acidic residues | |||
Region | 1-26 | Disordered | |||
Sequence similarities
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2.4) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)54,858
- Last updated1996-11-01 v1
- MD5 ChecksumC35046ECFCF4CE0C90E638A7B6E8E9FD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-11 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X75365 EMBL· GenBank· DDBJ | CAA53147.1 EMBL· GenBank· DDBJ | mRNA | ||
AC021665 EMBL· GenBank· DDBJ | AAG52225.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE35247.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY049275 EMBL· GenBank· DDBJ | AAK83617.1 EMBL· GenBank· DDBJ | mRNA | ||
BT020416 EMBL· GenBank· DDBJ | AAV97807.1 EMBL· GenBank· DDBJ | mRNA |