Q39027 · MPK7_ARATH
- ProteinMitogen-activated protein kinase 7
- GeneMPK7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids368 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
MKK3-MPK7 module acts as a positive regulator of PR1 gene expression.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Activated by threonine and tyrosine phosphorylation (By similarity).
Activated in response to hydrogen peroxide. Activation is triggered by MAPKKK17 and MAPKKK18 in a MKK3-dependent manner (PubMed:25720833).
Activated in response to hydrogen peroxide. Activation is triggered by MAPKKK17 and MAPKKK18 in a MKK3-dependent manner (PubMed:25720833).
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | MAP kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | defense response | |
Biological Process | response to hydrogen peroxide |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase 7
- EC number
- Short namesAtMPK7; MAP kinase 7
Gene names
- Community suggested namesMPK7
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ39027
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000186316 | 1-368 | Mitogen-activated protein kinase 7 | |||
Sequence: MAMLVEPPNGIKQQGKHYYSMWQTLFEIDTKYVPIKPIGRGAYGVVCSSINRETNERVAIKKIHNVFENRVDALRTLRELKLLRHVRHENVIALKDVMLPANRSSFKDVYLVYELMDTDLHQIIKSSQSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTSQGNEQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLIINVVGSQQESDIRFIDNPKARRFIKSLPYSRGTHLSNLYPQANPLAIDLLQRMLVFDPTKRISVTDALLHPYMAGLFDPGSNPPAHVPISLDIDENMEEPVIREMMWNEMLYYHPEAEISNA | ||||||
Modified residue | 191 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 193 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 196 | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Dually phosphorylated on Thr-191 and Tyr-193, which activates the enzyme.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 32-319 | Protein kinase | ||||
Sequence: YVPIKPIGRGAYGVVCSSINRETNERVAIKKIHNVFENRVDALRTLRELKLLRHVRHENVIALKDVMLPANRSSFKDVYLVYELMDTDLHQIIKSSQSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTSQGNEQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLIINVVGSQQESDIRFIDNPKARRFIKSLPYSRGTHLSNLYPQANPLAIDLLQRMLVFDPTKRISVTDALLHPYM | ||||||
Motif | 191-193 | TXY | ||||
Sequence: TEY |
Domain
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)42,299
- Last updated2002-06-06 v2
- Checksum64587E4CA40C1418
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 104 | in Ref. 1; BAA04870 | ||||
Sequence: S → T | ||||||
Sequence conflict | 303 | in Ref. 1; BAA04870 | ||||
Sequence: D → E | ||||||
Sequence conflict | 324 | in Ref. 1; BAA04870 | ||||
Sequence: D → E | ||||||
Sequence conflict | 327 | in Ref. 1; BAA04870 | ||||
Sequence: S → T | ||||||
Sequence conflict | 366 | in Ref. 1; BAA04870 | ||||
Sequence: S → L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D21843 EMBL· GenBank· DDBJ | BAA04870.1 EMBL· GenBank· DDBJ | mRNA | ||
AC007212 EMBL· GenBank· DDBJ | AAD31349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06734.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK222214 EMBL· GenBank· DDBJ | BAD95376.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |