Q38838 · AGL14_ARATH
- ProteinAgamous-like MADS-box protein AGL14
- GeneAGL14
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids221 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional activator that regulates root development by controlling meristem size and patterning of the root apical meristem. Regulates auxin transport and gradients in the root meristematic cells via direct regulation of the auxin efflux carrier PIN1 and PIN4 gene expression. Binds specifically to the CArG-box DNA sequences in the promoter regions of PIN1 and PIN4 genes (PubMed:24121311).
Involved in the regulation of shoot apical meristem (SAM) cell identities and transitions. Promotes flowering transition and participates in flower meristem maintenance and determinacy. Positively regulates TFL1 and WUS expression. Binds directly to the TFL1 regulatory sequences (PubMed:25636918).
Involved in the regulation of shoot apical meristem (SAM) cell identities and transitions. Promotes flowering transition and participates in flower meristem maintenance and determinacy. Positively regulates TFL1 and WUS expression. Binds directly to the TFL1 regulatory sequences (PubMed:25636918).
Miscellaneous
XAANTAL is the Mayan word for 'go slower' in recognition of the retarded root growth phenotypes of xaantal mutants.
Plants over-expressing AGL14/XAL2 show early flowering phenotype and flowers have vegetative traits.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | protein dimerization activity | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | flower development | |
Biological Process | maintenance of floral meristem identity | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of auxin polar transport | |
Biological Process | regulation of root meristem growth | |
Biological Process | vegetative to reproductive phase transition of meristem |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAgamous-like MADS-box protein AGL14
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ38838
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Retarded root growth, and altered root meristem size and stem-cell patterning (PubMed:24121311).
Late flowering phenotype (PubMed:25636918).
Late flowering phenotype (PubMed:25636918).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000199473 | 1-221 | Agamous-like MADS-box protein AGL14 | ||
Proteomic databases
Expression
Tissue specificity
Preferentially expressed in roots (PubMed:7549482).
Expressed in lateral root cap, root epidermis, root endodermis, columella of the root meristematic region, the vascular cylinder in differentiated zones of the primary root and in emerged lateral root primordia (PubMed:24121311).
Expressed in pollen (PubMed:12949148).
Expressed in lateral root cap, root epidermis, root endodermis, columella of the root meristematic region, the vascular cylinder in differentiated zones of the primary root and in emerged lateral root primordia (PubMed:24121311).
Expressed in pollen (PubMed:12949148).
Induction
By auxin.
Developmental stage
During floral transition, expressed very early at the flanks of the inflorescence meristem in the anlagens upon the transition to flowering Subsequently, expression levels increase in the first and second stages of the floral meristem and at stage 3, expression is restricted to the L1 and L2 layers. Later on, expressed in the gynoecium and stamen primordia at stage 6.
Gene expression databases
Interaction
Subunit
Interacts with AGL16.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q38838 | AGL24 O82794 | 6 | EBI-622067, EBI-592083 | |
BINARY | Q38838 | SVP Q9FVC1 | 4 | EBI-622067, EBI-592058 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length221
- Mass (Da)25,492
- Last updated2001-01-11 v2
- ChecksumE876DAEA049B125E
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B7Y6 | A0A1P8B7Y6_ARATH | AGL14 | 179 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 103 | in Ref. 4; AAC49082 | |||
Sequence conflict | 187-188 | in Ref. 4; AAC49082 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL078606 EMBL· GenBank· DDBJ | CAB44326.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161532 EMBL· GenBank· DDBJ | CAB78231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE83062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | ANM67706.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK230464 EMBL· GenBank· DDBJ | BAF02258.1 EMBL· GenBank· DDBJ | mRNA | ||
U20184 EMBL· GenBank· DDBJ | AAC49082.1 EMBL· GenBank· DDBJ | mRNA |