Q38832 · IAA14_ARATH
- ProteinAuxin-responsive protein IAA14
- GeneIAA14
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids228 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | auxin-activated signaling pathway | |
Biological Process | lateral root morphogenesis | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | response to auxin |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAuxin-responsive protein IAA14
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ38832
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 82 | In slr1-1; gain of function. Affects auxin-related developmental processes. | ||||
Sequence: P → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 35 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000112845 | 1-228 | Auxin-responsive protein IAA14 | |||
Sequence: MNLKETELCLGLPGGTETVESPAKSGVGNKRGFSETVDLKLNLQSNKQGHVDLNTNGAPKEKTFLKDPSKPPAKAQVVGWPPVRNYRKNVMANQKSGEAEEAMSSGGGTVAFVKVSMDGAPYLRKVDLKMYTSYKDLSDALAKMFSSFTMGSYGAQGMIDFMNESKVMDLLNSSEYVPSYEDKDGDWMLVGDVPWPMFVESCKRLRIMKGSEAIGLAPRAMEKFKNRS |
Proteomic databases
Expression
Tissue specificity
Preferentially expressed in roots and flowers.
Induction
By auxin.
Gene expression databases
Interaction
Subunit
Homodimers and heterodimers (By similarity).
Interacts with TPL
Interacts with TPL
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q38832 | ARF19 Q8RYC8 | 4 | EBI-2295562, EBI-529887 | |
BINARY | Q38832 | ARF5 P93024 | 3 | EBI-2295562, EBI-629519 | |
BINARY | Q38832 | ARF7 P93022 | 3 | EBI-2295562, EBI-632284 | |
BINARY | Q38832 | IAA1 P49677 | 3 | EBI-2295562, EBI-630505 | |
BINARY | Q38832 | IAA10 Q38828 | 3 | EBI-2295562, EBI-3946434 | |
BINARY | Q38832 | IAA12 Q38830 | 4 | EBI-2295562, EBI-617608 | |
BINARY | Q38832 | IAA13 Q38831 | 4 | EBI-2295562, EBI-1554143 | |
BINARY | Q38832 | IAA17 P93830 | 4 | EBI-2295562, EBI-632243 | |
BINARY | Q38832 | IAA19 O24409 | 4 | EBI-2295562, EBI-632257 | |
BINARY | Q38832 | IAA2 P49678 | 4 | EBI-2295562, EBI-632343 | |
BINARY | Q38832 | IAA26 Q8LAL2 | 4 | EBI-2295562, EBI-3947418 | |
BINARY | Q38832 | IAA27 Q9ZSY8 | 3 | EBI-2295562, EBI-3946677 | |
BINARY | Q38832 | IAA28 Q9XFM0 | 4 | EBI-2295562, EBI-3133404 | |
BINARY | Q38832 | IAA3 Q38822 | 4 | EBI-2295562, EBI-307174 | |
BINARY | Q38832 | IAA31 Q8H174 | 3 | EBI-2295562, EBI-3946408 | |
BINARY | Q38832 | IAA34 Q9C5X0 | 3 | EBI-2295562, EBI-3946459 | |
BINARY | Q38832 | IAA4 P33077 | 4 | EBI-2295562, EBI-632187 | |
BINARY | Q38832 | IAA5 P33078 | 4 | EBI-2295562, EBI-3946487 | |
BINARY | Q38832 | TCP15 Q9C9L2 | 3 | EBI-2295562, EBI-4426144 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 8-12 | EAR-like (transcriptional repression) | ||||
Sequence: LCLGL | ||||||
Domain | 110-210 | PB1 | ||||
Sequence: VAFVKVSMDGAPYLRKVDLKMYTSYKDLSDALAKMFSSFTMGSYGAQGMIDFMNESKVMDLLNSSEYVPSYEDKDGDWMLVGDVPWPMFVESCKRLRIMKG |
Domain
The N-terminal half of the protein contains two conserved domains I and II. Domain I includes a slightly degenerated ERF-associated amphiphilic repression (EAR) motif which seems to be involved in the activity of transcriptional repression. Domain II is required for the correct degradation of the protein through the SCF-mediated ubiquitin-proteasome pathway. Interactions between Aux/IAA proteins and auxin response factors (ARFs) occur through their C-terminal dimerization domains III and IV.
Sequence similarities
Belongs to the Aux/IAA family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length228
- Mass (Da)25,044
- Last updated2004-04-13 v2
- ChecksumA76A9F733538E372
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B7U4 | A0A1P8B7U4_ARATH | IAA14 | 234 | ||
A0A1P8B7U9 | A0A1P8B7U9_ARATH | IAA14 | 196 | ||
C0Z2L3 | C0Z2L3_ARATH | IAA14 | 183 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z97336 EMBL· GenBank· DDBJ | CAB46059.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161539 EMBL· GenBank· DDBJ | CAB78497.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE83459.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF334718 EMBL· GenBank· DDBJ | AAG50096.1 EMBL· GenBank· DDBJ | mRNA | ||
U18416 EMBL· GenBank· DDBJ | AAC49055.1 EMBL· GenBank· DDBJ | mRNA |