Q38361 · VINT_BPMD2
- ProteinIntegrase
- Gene33
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids374 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Integrase is necessary for integration of the phage into the host genome by site-specific recombination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 207 | |||||
Sequence: R | ||||||
Active site | 247 | |||||
Sequence: K | ||||||
Active site | 316 | |||||
Sequence: H | ||||||
Active site | 319 | |||||
Sequence: R | ||||||
Active site | 342 | |||||
Sequence: H | ||||||
Active site | 351 | O-(3'-phospho-DNA)-tyrosine intermediate | ||||
Sequence: Y |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | hydrolase activity | |
Molecular Function | transferase activity | |
Biological Process | DNA integration | |
Biological Process | DNA recombination | |
Biological Process | establishment of integrated proviral latency | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral genome integration into host DNA |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIntegrase
- EC number
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Fromanvirus
- Virus hosts
Accessions
- Primary accessionQ38361
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000197503 | 1-374 | Integrase | |||
Sequence: MAARRRGWGSLRTQRSGRVQASYVSPIDGQRYFGPRNYDNRMDAEAWLASEKRLIDNEEWTPPAEREKKAAASAITVEEYTKKWIAERDLAGGTKDLYSTHARKRIYPVLGDTPVAEMTPALVRAWWAGMGKQYPTARRHAYNVLRAVMNTAVEDKLVSENPCRIEQKAPAERDVEALTPEELDVVAGEVFEHYRVAVYILAWTSLRFGELIEIRRKDIVDDGETMKLRVRRGAARVGEKIVVGNTKTVRSKRPVTVPPHVAAMIREHMADRTKMNKGPEALLVTTTRGQRLSKSAFTRSLKKGYAKIGRPDLRIHDLRAVGATLAAQAGATTKELMVRLGHTTPRMAMKYQMASAARDEEIARRMSELAGITP |
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 75-153 | Core-binding (CB) | ||||
Sequence: ITVEEYTKKWIAERDLAGGTKDLYSTHARKRIYPVLGDTPVAEMTPALVRAWWAGMGKQYPTARRHAYNVLRAVMNTAV | ||||||
Domain | 173-364 | Tyr recombinase | ||||
Sequence: RDVEALTPEELDVVAGEVFEHYRVAVYILAWTSLRFGELIEIRRKDIVDDGETMKLRVRRGAARVGEKIVVGNTKTVRSKRPVTVPPHVAAMIREHMADRTKMNKGPEALLVTTTRGQRLSKSAFTRSLKKGYAKIGRPDLRIHDLRAVGATLAAQAGATTKELMVRLGHTTPRMAMKYQMASAARDEEIAR |
Sequence similarities
Belongs to the 'phage' integrase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length374
- Mass (Da)42,051
- Last updated2024-03-27 v3
- Checksum37B12A76857A43B1
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X70352 EMBL· GenBank· DDBJ | CAA49810.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
U81553 EMBL· GenBank· DDBJ | AAB69102.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
AF022214 EMBL· GenBank· DDBJ | AAC18476.2 EMBL· GenBank· DDBJ | Genomic DNA |