Q34949 · NU4M_LUMTE

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Molecular Functionubiquinone binding
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 4

Gene names

    • Name
      ND4

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Clitellata > Oligochaeta > Crassiclitellata > Lumbricina > Lumbricidae > Lumbricinae > Lumbricus

Accessions

  • Primary accession
    Q34949

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane57-77Helical
Transmembrane95-115Helical
Transmembrane116-136Helical
Transmembrane145-165Helical
Transmembrane186-206Helical
Transmembrane218-238Helical
Transmembrane251-271Helical
Transmembrane278-298Helical
Transmembrane303-323Helical
Transmembrane336-356Helical
Transmembrane360-380Helical
Transmembrane386-406Helical
Transmembrane428-448Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001179501-452NADH-ubiquinone oxidoreductase chain 4

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    452
  • Mass (Da)
    50,483
  • Last updated
    1996-11-01 v1
  • Checksum
    604CF0F63129DEDE
MLKLQMVLMSLLLLPLIVNLYPWIIALTLSALLLPTCFNLVNSASYSMFTEYMSSDMMSFTLSALTIWVTVMMILASTKIMHLNMYPKMFMTNLVILLIILINCFLSPNLIMFYIWFEASLIPTMVLIMTWGYQPERSQASMYLMIYTVAASLPMLMVLCKIFIVSKTAMMPMFMNMEFPMDYPSMALAWVLTLGGFLVKLPMFTVHLWLPKAHVEAPIAGSMILAAILLKLGGYGILRMLSLFHYMAKSTSSLLSSVALVGAVSTSLICLRQSDLKSLIAYSSVGHMGLMVAGALMSSNWGFQAALAMMIAHGLSSSALFVMANMNYELTHTRSLFLMKGLLVLAPTLTMWWFLFTASNMAAPPSINLLSEIMLITSILKMSTSAFILLGLTSFFTAAYCLYMYTSMHHGPLMLTSNPIPQFKVKDLTLMTMHLVPTILIIFKPELITSWS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U24570
EMBL· GenBank· DDBJ
AAC46873.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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