Q33E94 · RFX4_HUMAN

  • Protein
    Transcription factor RFX4
  • Gene
    RFX4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development. May be required for neural tube ciliogenesis during embryogenesis (By similarity).

Features

Showing features for dna binding.

1735100200300400500600700
TypeIDPosition(s)Description
DNA binding44-126
DNA binding61-136RFX-type winged-helix

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific double-stranded DNA binding
Biological Processcilium assembly
Biological Processnegative regulation of smoothened signaling pathway
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of protein processing
Biological Processregulation of transcription by RNA polymerase II
Biological Processtelencephalon development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor RFX4
  • Alternative names
    • Regulatory factor X 4
    • Testis development protein NYD-SP10

Gene names

    • Name
      RFX4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q33E94
  • Secondary accessions
    • A8K5Y0
    • B2RDW4
    • Q33DW6
    • Q33DW7
    • Q33E95

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_037873687
Natural variantVAR_057152698in dbSNP:rs17038766

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 807 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003142371-735Transcription factor RFX4

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1: Expressed in brain and gliomas (at protein level). Isoform 2: Testis-specific (at protein level). Isoform 3: Testis-specific (at protein level). Isoform 3: Expressed at a higher level in adult testes and ejaculated spermatozoa than in fetal testes. Isoform 4: Testis-specific.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer. Heterodimer with RFX2 and RFX3 (PubMed:11682486).
Interacts with GPS2 (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q33E94tax P140793EBI-9675925, EBI-9675698

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region27-59Disordered
Region315-487Necessary for dimerization
Region504-540Disordered

Sequence similarities

Belongs to the RFX family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q33E94-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    RFX4-D, RFX4_v3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    735
  • Mass (Da)
    83,368
  • Last updated
    2011-05-03 v2
  • Checksum
    9C2422428B9D7E8B
MHCGLLEEPDMDSTESWIERCLNESENKRYSSHTSLGNVSNDENEEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPVPSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGYTGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSVHSARYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK

Q33E94-2

  • Name
    2
  • Synonyms
    RFX4-C, RFX4_v4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-12: MHCGLLEEPDMD → MIKRRAHPGAGGDRTRPRRRR

Q33E94-3

  • Name
    3
  • Synonyms
    RFX4-A, RFX4_v1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-94: Missing
    • 95-126: TQPVNAASFGKIIRQQFPQLTTRRLGTRGQSK → MNWAAFGGSEFFIPEGIQIDSRCPLSRNITEW

Q33E94-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-12: MHCGLLEEPDMD → MIKRRAHPGAGGDRTRPRRRR
    • 546-554: AMQSYTWSL → NGKSFKNFG
    • 555-735: Missing

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
B4DZB7B4DZB7_HUMANRFX4247
F8VZC4F8VZC4_HUMANRFX459
F8VX50F8VX50_HUMANRFX439
F8VRD4F8VRD4_HUMANRFX4256
F8W1T9F8W1T9_HUMANRFX477
R4GMS3R4GMS3_HUMANRFX4145

Sequence caution

The sequence BAB59001.1 differs from that shown. Reason: Miscellaneous discrepancy Probable intron retention.
The sequence BAC11288.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAE48237.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAE48238.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0302431-12in isoform 2 and isoform 4
Alternative sequenceVSP_0302421-94in isoform 3
Alternative sequenceVSP_03024495-126in isoform 3
Sequence conflict417in Ref. 3; AAK17191
Sequence conflict423in Ref. 4; BAC11288
Sequence conflict477in Ref. 7; AAH28582
Sequence conflict522in Ref. 1; AAM52484
Alternative sequenceVSP_030245546-554in isoform 4
Sequence conflict549in Ref. 2; BAE48231/BAE48237/BAE48238 and 3; AAK17191
Alternative sequenceVSP_030246555-735in isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY102009
EMBL· GenBank· DDBJ
AAM52484.1
EMBL· GenBank· DDBJ
mRNA
AB095365
EMBL· GenBank· DDBJ
BAE48231.1
EMBL· GenBank· DDBJ
mRNA
AB095366
EMBL· GenBank· DDBJ
BAE48232.1
EMBL· GenBank· DDBJ
mRNA
AB195784
EMBL· GenBank· DDBJ
BAE48237.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AB195785
EMBL· GenBank· DDBJ
BAE48238.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AF332192
EMBL· GenBank· DDBJ
AAK17191.1
EMBL· GenBank· DDBJ
mRNA
AK074913
EMBL· GenBank· DDBJ
BAC11288.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK291445
EMBL· GenBank· DDBJ
BAF84134.1
EMBL· GenBank· DDBJ
mRNA
AK315698
EMBL· GenBank· DDBJ
BAG38061.1
EMBL· GenBank· DDBJ
mRNA
AC009721
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC079385
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471054
EMBL· GenBank· DDBJ
EAW97783.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471054
EMBL· GenBank· DDBJ
EAW97784.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471054
EMBL· GenBank· DDBJ
EAW97782.1
EMBL· GenBank· DDBJ
Genomic DNA
BC028582
EMBL· GenBank· DDBJ
AAH28582.1
EMBL· GenBank· DDBJ
mRNA
BC030644
EMBL· GenBank· DDBJ
AAH30644.1
EMBL· GenBank· DDBJ
mRNA
AB044245
EMBL· GenBank· DDBJ
BAB59001.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AL833921
EMBL· GenBank· DDBJ
CAD38777.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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