Q33DX5 · RMTC_PROMI
- Protein16S rRNA (guanine(1405)-N(7))-methyltransferase
- GenermtC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids281 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Specifically methylates the N7 position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides, including gentamicin and kanamycin.
Catalytic activity
- guanosine1405 in 16S rRNA + S-adenosyl-L-methionine = N7-methylguanosine1405 in 16S rRNA + S-adenosyl-L-homocysteine
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 60 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 105-107 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: HTS | ||||||
Binding site | 111 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 136 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 160 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 186-187 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: QG | ||||||
Binding site | 203 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 212 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | rRNA methyltransferase activity | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name16S rRNA (guanine(1405)-N(7))-methyltransferase
- EC number
- Alternative names
Gene names
Encoded on
- Plasmid pARS68
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Morganellaceae > Proteus
Accessions
- Primary accessionQ33DX5
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000416819 | 1-281 | 16S rRNA (guanine1405-N7)-methyltransferase | |||
Sequence: MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL |
Structure
Family & Domains
Sequence similarities
Belongs to the methyltransferase superfamily. Aminoglycoside resistance family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length281
- Mass (Da)32,106
- Last updated2005-12-06 v1
- ChecksumBA1342B4A198A7AE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB194779 EMBL· GenBank· DDBJ | BAE48305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU144360 EMBL· GenBank· DDBJ | ABX39521.1 EMBL· GenBank· DDBJ | Genomic DNA |